Elevated serum nitric oxide and hydrogen peroxide levels as potential valuable predictors of herpes zoster

Objective: To evaluate the biomarkers of oxidative stress in herpes zoster patients compared with control subjects. Methods: This study compared the nitric oxide (NO), hydrogen peroxide (H

Histopathological analysis from gallic acid administration on hippocampal cell density, depression, and anxiety related behaviors in a trimethyltin intoxication model

Objective: The present study investigated the effects of gallic acid [GA] administration on trimethyltin chloride [TMT] induced anxiety, depression, and hippocampal neurodegeneration in rats

Materials and Methods: In this experimental study, the rats received intraperitoneal [i.p.] injections of TMT [8 mg/kg]. The animals received either GA [50, 100 and 150 mg/kg] or saline as the vehicle for 14 consecutive days. We measured depression and anxiety levels of the rats by conducting the behavioral tail suspension [TST], elevatedplusmaze [EPM], and novelty suppressed feeding [NSF] tests. Histological analyses were then used to determine the cell densities of different hippocampal subdivisions. The data were analyzed with ANOVA and Tukey's post hoc test

Results: GA administration ameliorated anxiety and depression in the behavioral tests. The cell densities in the CA1, CA2, CA3 and DG hippocampal subdivisionsfrom GA-treated rats were higher than saline treated rats

Conclusion: GA treatment against TMT-induced hippocampal degeneration altered cellular loss in the hippocampus and ameliorated the depression-anxiety state in rats

Histopathological and behavioral assessment of toxin-produced cerebellar lesion: a potent model for cell transplantation studies in the cerebellum

The cerebellum is a key structure involved in coordinated motor planning, cognition, learning and memory functions. This study presents a permanent model of a toxin produced cerebellar lesion characterized according to contemporary motor and cognitive abnormalities. In this experimental study, slow administration of quinolinic acid [QA, 5 microl of 200 micromol, 1 microl/minute] in the right cerebellar hemisphere [lobule VI] caused noticeable motor and cognitive disturbances along with cellular degeneration in all treated animals. We assessed behavioral and histopathological studies over ten weeks after QA treatment. The data were analyzed with ANOVA and the student's t test. The QA treated group showed marked motor learning deficits on the rotating rod test [p