RESUMO
Objectives: To study mean platelet volume [MPV] in acute appendicitis and its correlation with leukocyte count
Study Design: Case control study
Place and Duration: Department of Surgery, Liaquat University of Medical and Health Sciences Jamshoro/Hyderabad from January 2013 to February 2014
Subjects and Methods: Subjects with clinical suspicion of acute appendicitis were selected according inclusion and exclusion criteria. A sample of 49 acute appendicitis patients and 37 controls were studied. The Blood samples were collected in sodium citrate vacutainers and processed on Sysmex KX 21 analyzers. The main analysis was the comparison of the difference of MPV between acute appendicitis and controls. Data was analyzed on SPSS version 21.0 by student's t-test, Chi-square test and Pearson's correlation [r] was used to evaluate association of MPV with platelet counts and leukocytes. A p-value of
Results: The mean platelet volume and leukocytes were significantly elevated in patients with acute appendicitis. MPV and leukocytosis in controls and cases were noted as 7.93 +/- 2.1 vs. 9.10 +/- 2.9fl [p=0.0001] and 6980 +/- 120 vs. 13980 +/- 340 micro L[-1] respectively. MPV was positively correlated with leukocytosis [r=0.419] [p=0.0001], while Platelets showed a negative correlation
Conclusion: Elevated MPV and leukocytosis are observed in acute appendicitis. MPV may be exploited for clinical diagnosis of acute appendicitis but in a proper clinical context along with leukocytosis