Videothermometry to evaluate metabolic activity in real time during pneumectomy in rats

Abstract Purpose: To evaluate, in rats, the open field videothermometry in real time while performing left pneumonectomy for early diagnosis of cardiopulmonary changes. Methods: Twelve non-specific pathogen-free Wistar rats were randomly allocated into two groups; pneumectomy group (GP) and sham surgery group (GS). Mean arterial pressure, videothermometry in real time, of the right lung, and histopathological analysis of the remaining lung were evaluated in all animals. Results: Videothermometry in real time allowed identification of temperature variance of right lung after pneumectomy, indicating a significant decrease in temperature during evaluation. There was a statistical difference between M0 and M1, M1 and M2 and M0 and M2 (p<0.004) in GS, and significant difference between M0 and M1, M1 and M2, and M2 and M0 with p<0.0001 in GP. Conclusions: Left pneumonectomy in rats shows initial histopathological changes after 60 minutes of its completion, indicating a possible compensation beginning. The open-field videothermometry in real time proved to be efficient identifying the temperature changes of the remaining lung.

Avaliação do seguimento oncológico de mulheres abaixo de 40 anos portadorasde câncer de mama em um hospital de referência da Amazônia / Evaluation of oncological women below 40 years old with breast cancer in a reference hospital in Amazon

Objetivo: Avaliar o seguimento de mulheres abaixo dos 40 anos com câncer de mama atendidas no Hospital Ophir Loyola no período de janeiro de 2008 a outubro de 2009. Métodos: Estudo epidemiológico, observacional, transversal e retrospectivo. Foram incluídas 92 pacientes cadastradas ao Hospital Ophir Loyola, Belém, Pará. Foi realizada revisão de prontuários e aplicação de questionários, após assinatura do Termo de Consentimento Livre Esclarecido e aprovação pelo Comitê de Ética em Pesquisa. Para a tabulação dos dados foi utilizado o software Microsoft Office Excel® 2007 e para a estatística o BioEstat 5.0. Resultados: Os tumores neoplásicos eram carcinoma ductal infiltrante em 87% (n=80); 41,3% (n=38) apresentaram topografia de neoplasia maligna da mama, sem outras especificações (SOE), sendo que 52,2% (n=48) se apresentam à direita e 45,7% (n=42) à esquerda. Notou-se que 64% (n=59) evoluíram com uma doença estável e 21% (n=19) a óbito. Dos óbitos, 53% (n=10) tinham entre 36 e 40 anos, com causa básica em 47% (n=9) de neoplasia maligna da mama, SOE e com 31,6% (n=6) com o óbito no primeiro e segundo ano de doença. Evoluíram com metástase 19,6% (n=18), sendo 50% (n=9) para ossos. Quanto ao estadiamento, 19,6% (n=18) no estágio IV e 28,3% (n=26) foram submetidas à cirurgia, radioterapia e quimioterapia. Conclusão: A partir deste estudo se mostra indispensável o esclarecimento aos profissionais da saúde quanto à importância do câncer de mama acometendo uma faixa etária mais precoce da população feminina, em busca de um diagnóstico e seguimento mais eficaz, diminuindo a morbimortalidade na população.

Objective: To evaluate the follow-up of women under 40 years old with breast cancer treated at Hospital Ophir Loyola from January 2008 to October 2009. Methods: Epidemiological, observational, cross-sectional and retrospective study. We included 92 patients enrolled in Hospital Ophir Loyola, Belém, Pará, Brazil. We performed chart review and questionnaires, after signing the consent form and approval by the Research Ethics Committee. For the tabulation of the data we used the software Microsoft Office Excel® 2007 and for the statistical analysis the BioEstat 5.0. Results: The neoplastic tumors were invasive ductal carcinoma 87% (n=80); 41,3% (n=38) showed the topography of malignant neoplasm of breast, not otherwise specified (SOE), and 52,2% (n=48) are presented to the right and 45,7% (n=42) to left. It was noted that 64% (n=59) presented stable disease and 21% (n=19) died. Of the deaths, 53% (n=10) were between 36?40 years old with underlying cause in 47% (n=9) of malignant neoplasm of breast, SOE and 31,6% (n=6), death the first and second year of the disease. Metastases were developed in 19,6% (n=18) being 50% (n=9) for bones. As for the staging, 19,6% (n=18) in stage IV and 28,3% (n=26) underwent surgery, radiation and chemotherapy. Conclusion: From this study it is indispensable to clarify health professionals about the importance of breast cancer affecting the earlier age of the female population, in search of a more effective diagnosis and management, reducing morbidity and mortality in the population.