RESUMO
Brown adipose tissue (BAT) increases energy consumption by directly dissipating stored energy in the form of heat through the role of uncoupling protein (UCP1). Recent studies have found that brown adipocytes may also regulate metabolism through autocrine, paracrine, and endocrine mechanisms. A growing body of evidences have shown that the BAT has a close relationship with bone metabolism, in which BAT secretes a variety of factors to regulate bone metabolism, while bone also secretes a variety of bioactive substances to control BAT function. In addition, BAT may indirectly participate in bone metabolism through muscle-mediated regulation or SNS activity and improvement of body metabolism, thus forming a BAT-skeletal axis. In this paper, we try to explain the relationship between brown adipose tissue and bone, and to discuss their interactive mechanisms.
RESUMO
Two hundred and thirty nine patients with type 2 diabetes mellitus (T2DM) managed in the community health service centers of Huai'an city were selected for survey by random sampling method between January and December 2017.A self-designed questionnaire was used to assess self-management prescription.Patients received community management for 3 months.The rates of patients with not receiving diabetes health education,with healthy diet,with regular exercise,without monitoring blood glucose,with repeated hypoglycemic attacks were 44.8％ (107/239),23.0％ (55/239),46.4％ (111/239),54.8％ (131/239)and 21.3％(23/108),respectively;and 51.9％ (124/239) of the participants did not adhere to medication.The awareness rate of diabetic complications was 27.2 ％ (65/239).Only 25.1％ (60/239) and 15.1％ (36/239) of the participants apply oral hypoglycemic agents and insulin rationally.The survey results indicate that the current status of self-management in community diabetic patients is relatively poor,it is necessary to strengthen standardized management of diabetic patients in community health institutions.