RESUMO
Objective To evaluate the effects of treating gouty arthritis with modified Simiao decoction and external application of traditional Chinese medicine. Methods 76 patients with gouty arthritis of our hospital from January 2010 to August 2013 were recruited and randomly divided into a treatment group and a control group, 38 patients in each group. Patients in both groups were given low caloric diet, large amount of water(>2 000 ml), and forbidden to smoking, alcohol, sea food, animal splanchna and bean products. The control group was treated with oral intake of colchicines and indometacin in acute stage and oral intake of diclofenc in stable stage, while the treatment group was further added modified Simiao decoction and external application of traditional Chinese medicine on the basis of the control group. TCM symptom score, arthritis symptom score, symptomatic relief time, ESR, CRP, UA, IL-1?and IL-18 were observed after 7 days treatment. Results CRP, ESR decreased after the treatment[The treatment group respectively(22.06±10.31)mg/L, (25.18±17.80)mm/h,the control group respectively(14.11±7.32)mg/L, (24.16±22.09)mm/h]in both groups compared with the values before the treatment[The treatment group respectively(82.16±21.37)mg/L, (72.13± 32.36)mm/h,the control group respectively(52.46±22.26)mg/L, (62.72±33.31)mm/h, P<0.01],while the decrease after of ESR in the treatment group was much obvious than the control group(P<0.05). IL-1?, IL-18 decreased after the treatment[The treatment group respectively(55.26±16.31)pg/ml, (187.32±50.38)pg/ml;the control group respectively(57.25±18.21)pg/ml, (178.49±52.60)pg/ml] in both groups compared with the values before the treatment[The treatment group respectively(106.11±41.02)pg/ml, (398.15±132.52)pg/ml.The control group respectively(109.23±40.12)pg/ml, (397.16±141.21)pg/ml, P<0.01]. The symptomatic relief time was(4.02±2.08)d and(4.95±2.68)d in the treatment group and the control group respectively, showing statistical difference between the two groups(P<0.05). Conclusion Modified Simiao decoction combined with external application of Chinese medicines reduced TCM symptom score and arthritis symptom score, increase symptomatic relief time, decrease ESR, CRP and UA level, and enhance body immunity.