Mutagenic activity of monochloramines and dichloramines in salmonella typhimurium

Mutagenic activity of ethanolamine mono-and dichloramines, histamine mono and dichloramines, and taurine mono- and dichloramines was studied in vitro using the S.tvphimurium strains TA 98 and TA 100. TA 100 was the most sensitive strain to mono-and dichloramines, and, when incubated the most active mutagens were ethanolamine and histamine dichloramines. Chloramines such as taurine mono or dichloramines were inactive. Glucose metabolism of the bacteria was critical to determine the mutagenicity. Chloramines were mutagenic when added to bacteria with glucose at 37°C, but killing predominated when chloramines were added at 4°C or 15°C, or at 37°C without glucose