[Adenocarcinoma of the oeso-gastric junction on endobrachyoesophagus. About two cases review of literature]

Barrett esophagus [BE] is intestinal metaplasia [MI] within the distal tubular esophagus. The BE results in replacement of the normal squamous-lined epithelium with a columnar type epithelium. This metaplastic lesion is a clearly defined risk factor for the development of esophageal adenocarcinoma [ADC]. In the western countries the incidence of adenocarcinoma of the lower esophagus and the gastro-esophagus junction have rapidly increased during the past twenty years. The 5-year survival is very poor. Although the relative risk of individuals in the United States with BE developing esophageal adenocarcinoma is very high, the absolute risk is extremely low due to the small number of cases. This lesion is caused by a persistent gastro-esophageal reflux. The nature of the reflux liquid is mixed acid and alkaline in the big majority of cases. A familial aggregation of BE and esophageal adenocarcinoma are present in 14% of patients with BE and esophageal adenocarcinoma. The diagnosis, the surveillance, the new tools of characterization of BE and the therapy remain an actual problem. We present 2 cases of endobrachyesophagus associated to an adenocarcinoma of the lower esophagus and a review of the main actual problem

Tumeurs stromales gastriques: presentation de deux cas avec etude immunohistochimique. revue de la litterature

GSTs are uncommon mesenchymal tumors of the stomach. The evaluation of malignancy is difficult and their histogenesis is controversial. Recently a relationship to the pacemaker interstitial cells of Cajal [ICC] has been suggested because GSTs, like the ICC express CD117 [C-K1T protein]. Some authors, like Miettinen in one of his studies, consider the CD117 positivity as part of the definition of GSTs. The purpose of this paper is to present two cases of GST with immunohistochemical study confirming the diagnosis of GST; the immunoreactivity of these two tumors is positive for CD117 and negative for protein S-100, actine and desmin. A review of the clinicopathologic, the immunohistochemical features, the prognostic factors and novelties in treatment will be presented

carcinome adenoide kystique du sein. A propos d'un cas

We report a case of adenoid cystic carcinoma of the breast in a 62-year-old lady. This tumor is a rare histologic form of breast cancer, associated with a favorable prognosis, and a special clinical behavior. It is mainly diagnosed on morphological grounds, by identifying two populations of neoplastic basaloid myoepithelial and epithelial cells with extracellular deposits of eosinophilic basement membrane-like substance. Lymph node metastases are rare. Partial or simple mastectomy is an adequate treatment. Axillary lymph node dissection may not be necessary

goitres plongeants

In a series of 363 patients operated for goiter, 60 were retrosternal [16,5%]. The female incidence although less than in cervical goiters remains predominant [2,5:1]. Most patients are in older age group, 68% being above 40 years. The majority of goiters are multinodular and of long duration. Bilateral [37%] and left sided location [43%] were common. The incidence of cancer was 7%, thyrotoxicosis was noted in 5 patients [8%]. Most patients were symptomatic [97%]. Diagnosis is easily done by physical examination, chest X-Ray and thyroid scintigraphy. Computed tomography might be helpful. Retrosternal goiter is an indication to surgery except in high risk patients. The cervical approach has been used in 98% of cases. There were no postoperative death and no major complications [compressive hematoma, laryngeal nerve paralysis, hypocalcaemia]