RESUMO
La proteína C-reactiva ultrasensible (PCR-us) es un biomarcador importante en procesos inflamatorios. El objetivo del estudio fue examinar la relación entre la concentración de la PCR-us de adultos aparentemente sanos, con su patrón alimentario característico del norte de México. A una muestra de 72 profesores universitarios se les realizó una valoración clínica y antropométrica y se les cuantificó la PCR-us con un ensayo inmunoenzimométrico (EIA). Los profesores además contestaron un cuestionario de frecuencia de consumo de alimentos, del cual se estimaron las raciones de grupos de alimentos con el programa ESHA. La edad promedio de los participantes fue 49,75 ±10,05 años y la concentración de PCR-us tuvo un promedio de 1,66 (0,97 a 3,52) mg/L. La magnitud de la asociación entre el consumo de frutas y el nivel de PCR-us fue protectora de acuerdo con el análisis de regresión logística cuya Razón de Momios (RM) fue de 0,23 (95% IC: 0,05 a 1,03), mientras que para los vegetales la RM fue de 0,66 (95% IC: 0,12 a 3,68). Por otro lado, los alimentos proteicos, lácteos, aceites y grasas se asociaron con niveles elevados de la PCR-us. En conclusión, la menor concentración de la PCR-us se asoció con la mayor ingesta de los grupos de frutas y vegetales, y en menor grado con los cereales.
The high sensitivity C-reactive protein (hs-CRP) is an important biomarker in inflammatory processes. The objective was to analyze the relationship between the concentrations of hs-CRP in adults from a northern Mexico region with their typical food intake patterns. A sample of 72 university professors underwent clinical and anthropometric assessments and their hs-CRP levels were quantified with an immunoenzymometric assay. Additionally, they filled out a food intake frequency questionnaire, from which the servings of different food groups were obtained with the ESHA software. The average age of participants was 49.75 ± 10.05 years and the average hs-CRP concentration was 1.66 (0.97, 3.52) mg/L. The value of the association between fruit consumption and hs-CRP level was protective, according to the logistic regression analysis, being the Odds Ratio (OR) 0.23 (95% CI: 0.05, 1.03); while for vegetables the OR was 0.66 (95% CI: 0.12, 3.68). Furthermore, high protein content foods, dairy products, oils and fats were associated with elevated levels of hs-CRP. In conclusion, in our study, the intake of some food groups like fruits and vegetables, and to a lesser extent cereals, were associated with low values of hs-PCR.
Assuntos
Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Proteína C-Reativa/análise , Dieta , Inflamação/sangue , Antropometria , Laticínios , Gorduras na Dieta , Grão Comestível , Comportamento Alimentar , Frutas , Alimentos/classificação , Inflamação/epidemiologia , Inflamação/etiologia , Carne , México , Valores de Referência , VerdurasRESUMO
Background: Rheumatoid arthritis (RA) is associated with a decrease in insulin sensitivity (IS), which has been identified as an independent risk factor for the development of early atherosclerosis. Hydroxychloroquine (HCQ) may have beneficial effects on glucose homeostasis and lipid profile. Aim: To assess the effect of HCQ on IS and lipid profile in patients with RA. Material and Methods: An open clinical trial was performed in 15 patients aged between 35 and 56 years. During three months, patients received 400 mg/day of HCQ orally. Before and after the pharmacological intervention, demographic and anthropometric variables, serum glucose, total cholesterol (TC), triglycerides (TG), HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, insulin and uric acid were measured. IS was estimated as the rate of glucose clearance per minute obtained with the insulin tolerance test (KITT). Results: Baseline and final KITT values were 4.3 ± 1.2 and 4.80 ± 1.1%/min, respectively (p = 0.03). Significant reductions in serum TC (p = 0.04) and TG (p = 0.01) were also observed. No other significant differences were observed. Conclusions: Oral administration of 400 mg/day of HCQ during three months in RA patients is associated with an improvement in IS, TC and TG.