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Chinese Journal of Natural Medicines (English Ed.) ; (6): 786-790, 2015.
Artigo em Inglês | WPRIM | ID: wpr-812481

RESUMO

The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities of the isolated compounds were assessed in rats with hot plate test and paw pressure assay. Two new flavone C-glycosides, named as Sacroroside A and B (Compounds 1 and 2) were isolated from the EtOAc crude extract of the aerial parts ofArtemisa sacrorum Ledeb. They showed significant analgesic effects. In conclusion, Compounds 1 and 2 are new natural products, which show significant analgesic effects in a dose-dependent manner.


Assuntos
Animais , Masculino , Analgésicos , Química , Farmacologia , Usos Terapêuticos , Artemisia , Química , Dissacarídeos , Química , Farmacologia , Usos Terapêuticos , Flavanonas , Química , Farmacologia , Usos Terapêuticos , Flavonas , Química , Farmacologia , Usos Terapêuticos , Temperatura Alta , Estrutura Molecular , Dor , Tratamento Farmacológico , Fitoterapia , Componentes Aéreos da Planta , Extratos Vegetais , Química , Farmacologia , Usos Terapêuticos , Pressão , Ratos Wistar
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