A cohort study on the relationship between body mass index and blood pressure, blood lipid, blood glucose, left ventricular structure and function in adolescents during transition period / 中华流行病学杂志

<p><b>OBJECTIVE</b>To investigate the relationship between body mass index(BMI) and blood pressure, blood lipid level, blood glucose, left ventricular structure and function in adolescents during transition period.</p><p><b>METHODS</b>A vertical sectional survey on 193 pupils aged 7-11 years in primary school in 1996 was performed. 9 years later, the same research subjects aged 16-20 years were studied again in 2005. The subjects were divided into obesity,overweight and normal weight groups according to their BMI in 1996. Height, body weight, blood pressure, total cholesterol, triglyceride and blood glucose were collected and analyzed, and left ventricular structure and function were examined by echocardiography.</p><p><b>RESULTS</b>Body mass index (24.71 kg/m(2)+/-4.57 kg/m(2), 20.54 kg/m(2)+/-2.84 kg/m(2) ), systolic blood pressure (117.22 mm Hg+/-17.44 mm Hg vs. 102.20 mm Hg+/-11.68 mm Hg), thickness of inter-ventricular septum and posterior wall (0.87 cm+/-0.12 cm vs. 0.77 cm+/-0.12 cm, and 0.91 cm+/-0.13 cm vs. 0.79 cm+/-0.31 cm), left ventricular mass and mass index (167.84 g+/-16.29 g vs. 128.95 g+/-63.00 g, and 88.12 g/m(2) +/-17.19 g/m(2) vs. 79.35 g/m(2)+/-39.01 g/m(2)) were found significantly higher in obesity group than in normal weight group 9 years later (P<0.05, P< 0.01 or P< 0.001). End diastolic volume and cardiac output were increased(P <0.05) and ejection fraction and fractional shortening decreased( P< 0.05). There were no differences found in cardiac diastolic function between the studied groups.</p><p><b>CONCLUSION</b>The results suggested that simple obesity in childhood was an important cardiovascular risk factor when they grew into adolescents and adults. ;</p>

Effect of E-selectin A561C (S128R) polymorphism on blood pressure / 中华心血管病杂志

<p><b>OBJECTIVE</b>To investigate the effect of E-selectin A561C (S128R) polymorphism on blood pressure.</p><p><b>METHODS</b>347 essential hypertensive patients (male 163 and female 184, age 46.08 +/- 12.49 y, and body mass index 26.13 +/- 3.14 kg/m(2)) and 315 normal controls (male 93 and female 222, age 42.21 +/- 14.67 y, and body mass index 25.66 +/- 3.19 kg/m(2)) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Phenotypic measurements included blood pressure, blood glucose, serum triglycerides, serum total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, serum uric acid, blood urea nitrogen, nitric oxide, endothelin, angiotensin I, and II and plasma aldosterone.</p><p><b>RESULTS</b>The frequencies of the AC and CC genotypes (6.92%) and C allele (4.76%) were significantly (P = 0.029 and 0.013) higher in hypertensive patients than normal controls (3.17% and 2.22%). The relative risk of hypertension associated with the C allele was 2.197 (95% CI: 1.164-4.144). Both diastolic blood pressure and mean arterial pressure were higher in C allele carriers than AA subjects (P = 0.049 and 0.024). Furthermore, C allele carriers, compared with AA subjects, had higher concentrations of blood glucose, and total and LDL cholesterol (P = 0.031, 0.046, and 0.003) and lower concentrations of nitric oxide (P = 0.036).</p><p><b>CONCLUSION</b>The E-selectin A561C (S128R) polymorphism might affect blood pressure in Chinese.</p>

A study on the risk factors of cardiovascular between hypertensive patients and normal subjects in the same family / 中华流行病学杂志

<p><b>OBJECTIVE</b>Through studying the difference between the hypertensive patients and those with normal blood pressure who all from the same hypertensive pedigree, we tried to find the factors which would decrease the risk of hypertension.</p><p><b>METHODS</b>Hypertensive patients, when coming to the cardiovascular clinic of Xuan Wu Hospital from 2003 to 2004, were defined as the members of the hypertensive pedigrees through inquiry. 84 families including 368 persons, with 192 syblings were involved. Metabolic syndrome could be defined by the criterion of adult treatment panel III.</p><p><b>RESULTS</b>When compared with normal blood pressure persons, clinical examinations of the hypertensive patients had an higher levels of triglyceride, total cholesterol, glucose and body mass index (BMI). The hypertensive group showed higher ratios among male patients, smokers, alcohol drinkers, having irritable personality and high-salt-intake. Through logistic regression, overweight, smoking and irritable temperament showed positive relations with hypertension. The rate of metabolic syndrome was higher in hypertension group.</p><p><b>CONCLUSION</b>It is important that either persons with normal blood pressure or hypertension should control their body weights (BMI) since the rate of metabolic syndrome in hypertension group was high.</p>

Relationship between the patients' knowledge on hypertension prevention and control and the rate on blood pressure control / 中华流行病学杂志

<p><b>OBJECTIVE</b>To study the relationship between blood pressure control status and patients' knowledge on hypertension prevention and control among hypertensive patients.</p><p><b>METHODS</b>A total of 726 hypertensives were selected from four community health service centers (2 urban and 2 rural) in Beijing. All subjects were investigated by questionnaires and their blood pressures were measured at the same time.</p><p><b>RESULTS</b>The rate for blood pressure under control (< 140/90 mm Hg, 1 mm Hg = 0.133 kPa) in the rural and urban patients were 46.4% and 23.9% respectively. The control rate increased with the increase of patients' knowledge on prevention and control of hypertension in both urban and rural patients. The cumulative effect of knowledge on hypertension control status could contribute 30.0% to the difference in hypertension control rate between rural and urban patients.</p><p><b>CONCLUSION</b>Patients' knowledge on hypertension control was significantly related to the rate on hypertension control. Health education should be helpful to improve the rate on hypertension control.</p>