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1.
Southeast Asian J Trop Med Public Health ; 2008 May; 39(3): 571-4
Artigo em Inglês | IMSEAR | ID: sea-32897

RESUMO

Blood donor selection contributes to the safety of both the donor and the recipient. The objective of this study was to identify the number and causes of blood pre-donation deferrals at the Hospital Universiti Sains Malaysia (HUSM). A retrospective study was carried out to retrieve data regarding deferred blood donors at the HUSM in the year 2006. A total of 4,138 blood donors donated blood at the Transfusion Medicine Unit, of whom 231 were deferred or rejected as donors. The percentage of deferred donors was 5.6%. The main reason for deferral was a low hemoglobin (40.7%), with females constituting the majority of those deferred. This was followed by high blood pressure (29.4%) and male donors were predominant in this group. Medical illness caused 15.6% of donor deferrals. The majority of deferred donors were regular donors (64.1%). We recommend setting new hemoglobin criteria for donor deferral according to the reference range obtained for the particular population. Most of the other deferrals were preventable by proper health care education and awareness.


Assuntos
Adolescente , Adulto , Doadores de Sangue , Seleção do Doador , Feminino , Hospitais de Ensino , Humanos , Malásia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco
2.
Southeast Asian J Trop Med Public Health ; 2007 Nov; 38(6): 1070-4
Artigo em Inglês | IMSEAR | ID: sea-30957

RESUMO

The objective of this study was to determine the prevalence and trends in hepatitis B infection among blood donors attending the Transfusion Medicine Unit at the Hospital Universiti Sains Malaysia, Kelantan, Malaysia. A retrospective study was carried out by reviewing the results of HBsAg among blood donors for the years 2000 to 2004. During this period, 44,658 blood donors were studied. We noted that there was a significant difference in the prevalence of hepatitis B infection between regular and first time donors. There was also a decreasing trend noticed in both study groups. The mean prevalence was significantly different between first time (1.83%) and regular donors (0.45%) (p < 0.005). There is a need to improve public awareness programs to lower the incidence of hepatitis B infection in the general population and consequently first time blood donors. Future studies are also required to determine the trends and outcomes of these programs.


Assuntos
Doadores de Sangue , Feminino , Hepatite B/epidemiologia , Antígenos de Superfície da Hepatite B/sangue , Vírus da Hepatite B , Humanos , Malásia/epidemiologia , Masculino , Estudos Retrospectivos
3.
Southeast Asian J Trop Med Public Health ; 2007 May; 38(3): 543-5
Artigo em Inglês | IMSEAR | ID: sea-34452

RESUMO

Thalassemia is a common public health problem among Malays. Hemoglobin C (Hb C) is a hemoglobin beta variant resulting from a single base mutation at the 6th position of the beta-globin gene leading to the substitution of glycine for glutamic acid. Hb C is commonly detected in West Africans and in African American but has not been reported in Malaysia. It can be falsely diagnosed as HbE trait in the Malaysian Thalassemia Screening Program which utilizes cellulose acetate hemoglobin electrophoresis. This is the first reported case of Hb AC heterozygote status in a Malay family, with unusual splenomegaly in one of the family members.


Assuntos
Criança , Cromatografia Líquida de Alta Pressão , Tomada de Decisões , Eletroforese em Acetato de Celulose , Família , Feminino , Hemoglobinas Anormais/análise , Humanos , Malásia , Talassemia/sangue
4.
Southeast Asian J Trop Med Public Health ; 2006 Mar; 37(2): 370-3
Artigo em Inglês | IMSEAR | ID: sea-35492

RESUMO

Iron deficiency is the commonest cause of anemia worldwide and healthy blood donors are estimated to lose about 236 mg of iron with each donation. The objective of this study was to determine the serum ferritin levels among first time and regular male blood donors, and also to correlate the serum ferritin levels with the number of donations and hemoglobin levels. Hemoglobin levels and serum ferritin were measured in three groups of donors divided into first time donors; (n = 92), donors with 2-4 donations (n = 41), and regular donors (n = 78). The mean hemoglobins in the first time donors, second group and regular blood donor group were 14.95 +/- 1.08, 15.12 +/- 1.44 and 15.56 +/- 1.48, respectively. The serum ferritin level were found to be significantly lower among the regular donors (62.0 +/- 39.78 ng/ml) compared to first time donors (90.7 +/- 66.63) and second group donors (114.12 +/- 66.97). The serum ferritin levels gradually decrease according to the number of donations and there was a significant correlation between frequency of donations and the serum ferritin level (r2 = 0.082). Significant correlation between the number of donations and hemoglobin level r2 = 0.061) was noted. However, there was no significant correlation between hemoglobin and serum ferritin levels (r2 = 0.015). Eleven percent of regular donors had depleted iron stores. This was not noted in donors who donated less than 5 times within 2 years.


Assuntos
Adulto , Anemia Ferropriva/diagnóstico , Doadores de Sangue , Ferritinas/sangue , Hemoglobinas/análise , Humanos , Ferro/sangue , Malásia/epidemiologia , Masculino , Estudos Prospectivos , Fatores de Tempo
5.
Southeast Asian J Trop Med Public Health ; 2006 Mar; 37(2): 294-6
Artigo em Inglês | IMSEAR | ID: sea-32707

RESUMO

Human cytomegalovirus (HCMV) is a species-specific DNA virus of the Herpetoviridae family. After a primary infection, HCMV persists in a latent form most probably in bone marrow progenitor cells or in peripheral blood monocytes. The virus can reactivate to result in shedding of the virus leading to virus dissemination and new infections. Immunocompromized patients are the ones most vulnerable to serious diseases occasionally acquired in blood transfusions. In a human population, HCMV seropositivity increases steadily with age to become approximately 100% in adults. This study was performed to detect seropositivity among regular blood donors in The Hospital of the Universiti Sains Malaysia, in the state of Kelantan. Using an enzyme immunoassay, it was found that 97.6% of blood donors were HCMV-positive. HCMV is highly prevalent and may be endemic in Kelantan. Hence, long-term strategies are required for the reduction of disease dissemination, and to prevent the exposure of immunocompromized patients to the virus.


Assuntos
Adolescente , Adulto , Anticorpos Antivirais/sangue , Doadores de Sangue , Citomegalovirus/imunologia , Infecções por Citomegalovirus/epidemiologia , Feminino , Humanos , Técnicas Imunoenzimáticas/métodos , Malásia/epidemiologia , Masculino , Pessoa de Meia-Idade , Estudos Soroepidemiológicos
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