RESUMO
Alopecia areata [AA] is suspected as one of the autoimmune disease. There are conflicting results about the presence of autoantibodies in patients with AA. Forty patients with AA and other thirty normal subjects as a control were studied for the presence of autoantibodies such as antinuclear [ANA], anti- smooth muscle [ASMA] and antimitochondrial [AMA] antibodies using indirect immunofluorescence technique. Autoantibodies were found in [55.5%] of patients and [20%] of the control this difference was statistically significant P< 0.001 ; the commonest was The ASMA that was present in [37.5%], followed by ANA [25%] of the patients; while AMA was detected in [5%]. A family history of AA was reported [20%] of the patients, while [25%] of the patients has a family history of atopy. There was no significant difference between female and male patients in the presence of different studied autoantibodies. From these results we recommend the investigation of cases of AA specially those with more than 3 months duration for autoantibodies to modify the line of treatment of autoimmune disease