Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Adicionar filtros








Intervalo de ano
1.
Mem. Inst. Oswaldo Cruz ; 102(3): 405-410, June 2007. tab
Artigo em Inglês | LILACS | ID: lil-452520

RESUMO

Antibody responses directed against the Plasmodium falciparum antigens, total extract, anti-merozoite surface protein-3 (MSP3b) and glutamate-rich protein (Glurp-R0) were studied in 42 children exposed to both Schistosoma haematobium and P. falciparum infections. The association between levels of the anti-malaria IgG subclasses and IgM with host age, sex, schistosome infection intensity and schistosome specific antibodies was studied before chemotherapeutic treatment of schistosome infections. This showed a significant negative association between schistosome infection intensity and levels of IgG1, IgG3, and IgG4 directed against malaria total extract antigen, and a positive association between levels of anti-schistosome soluble egg antigen IgG2, IgG3, and IgG4 and levels of the same subclasses directed against malaria total extract antigens. The effect of treating schistosome infections with praziquantel on malaria specific responses was also studied. This treatment resulted in increases in significant IgG4 levels against MSP3b and IgM against Glurp R0. Treatment also resulted in a significant decrease in IgG4 levels against Glurp R0. Host age, sex or pre-treatment infection intensity was not associated with the magnitude of change in the two IgG4 responses while males showed a significantly higher increase in levels of IgM. The results suggest cross reactivity between schistosome and malaria antigens in this population.


Assuntos
Humanos , Animais , Masculino , Feminino , Criança , Adolescente , Imunoglobulina G/imunologia , Malária Falciparum/imunologia , Fragmentos de Peptídeos/imunologia , Proteínas de Protozoários/imunologia , Esquistossomose Urinária/imunologia , Especificidade de Anticorpos , Anti-Helmínticos/uso terapêutico , Anticorpos Antiprotozoários/imunologia , Antígenos de Protozoários/imunologia , Reações Cruzadas , Ensaio de Imunoadsorção Enzimática , Imunoglobulina G/sangue , Imunoglobulina G/classificação , Malária Falciparum/complicações , Malária Falciparum/tratamento farmacológico , Plasmodium falciparum/imunologia , Praziquantel/uso terapêutico , Schistosoma haematobium/imunologia , Esquistossomose Urinária/complicações , Esquistossomose Urinária/tratamento farmacológico
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA