RESUMO
Effects of medroxy progesterone acetate (MPA; 5 mg/kg) and MPA + testosterone enanthate (TE) (3 mg + 2 mg/kg) were investigated in vas deferens and on fertility (along with reversibility study) for 60 days through histopathology, morphometric and certain biochemical parameters such as total proteins, sialic acid, ATPase, SDH and testosterone. The study revealed for altered histopathology and contratile pattern of vas deferens resulting in reduced fertility. The study also indicated androgen antagonistic effect. These effects were found to be reversible 4 and 3 months after withdrawal of MPA and MPA + TE injections respectively. Thus, both types generated functional sterility in the rat, but MPA affected histophysiology of vasal tissue.
Assuntos
Animais , Fertilidade/efeitos dos fármacos , Masculino , Acetato de Medroxiprogesterona/farmacologia , Contração Muscular/efeitos dos fármacos , Ratos , Contagem de Espermatozoides/efeitos dos fármacos , Motilidade dos Espermatozoides/efeitos dos fármacos , Testosterona/análogos & derivados , Ducto Deferente/efeitos dos fármacosRESUMO
Bimonthly injections (im) of medroxyprogesterone acetate (MPA, 5 mg/0.2 ml) and testosterone enanthate (TE, 2.5 mg/0.2 ml) to rats for 30 and 60 days induced oligospermia. The sperms from epididymis had defective metabolism, alterations in their morphology, viability and acrosome integrity. Thus this altered sperm function resulted in reduction in the fertility rate of MPA+TE treated animals.