Preventive and curative effects of ginger extract against histopathologic changes of gentamicin-induced tubular toxicity in rats

Gentamicin [GM] is a commonly used aminoglycoside, however, renal toxicity has limited its usage. This study was designed to evaluate the curative and protective effects of Zingiber officinale [ginger] against gentamicin tubular toxicity in rats. The phenolic and flavonoid components and antioxidant activity of ginger were also evaluated. In a preclinical study, 50 male Wistar rats were designated into 5 groups of 10 and treated as follows: Group I: vehicle. Group II: 200 mg/kg/d of ginger for 3 days then, GM [80 mg/kg] for 7 days. Group III: 200 mg/kg ginger orally for 3 days, then ginger plus GM for 7 days. Group IV: GM for 7 days. Group V: GM for 10 days. Group VI: GM for 7 days, then 200 mg/kg ginger orally for 10 days. At the end of the study, the animals were sacrificed and their kidneys were histologically evaluated. Ginger could prevent degeneration of the renal cells and reduce the severity of tubular damage caused by gentamicin. However, it could not regenerate the GM degeneration. The results indicate that ginger is effective as a prophylaxis agent, but has not curative effect

Suppressive impact of anethum graveolens consumption on biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits

We aimed to determine the effects of Anethum graveolens [Dill] powder on postprandial lipid profile, markers of oxidation and endothelial activation when added to a fatty meal. In an experimental study, 32 rabbits were randomly designated into four diet groups: normal diet, high cholesterol diet [1%], high cholesterol diet plus 5% [w/w] dill powder and high cholesterol diet plus lovastatin [10 mg/kg, bw]. The concentrations of glucose, total cholesterol [TC], low density lipoproteins cholesterol [LDL C], alanine aminotransferase [alt], aspartate aminotransferase [ast], fibrinogen, factor VII, apolipoprotein B [ApoB], nitrite and nitrate were measured in blood samples following 15 h of fasting and 3 h after feeding. Concurrent use of A. graveolens powder or lovastatin significantly decreased ALT, TC, glucose, fibrinogen and LDL C values in comparison with hypercholesterolemic diet group [P < 0.05]. Consumption of A. graveolens or lovastatin did not change factor VII, ApoB, nitrite and nitrate levels significantly in comparison with hypercholesterolemic diet group. Intake of A. graveolens significantly decreased serum AST compared to hypercholesterolemic diet. A. graveolens might have some protective values against atherosclerosis and that it significantly affects some biochemical risk factors of this disease. Our findings also confirm the potential harmful effects of oxidized fats and the importance of dietary polyphenols in the meal