RESUMO
<p><b>OBJECTIVE</b>To study the influence of micrometastasis in lymph node on staging and prognosis of non-small-cell lung cancer (NSCLC).</p><p><b>METHODS</b>In 39 NSCLC patients, micrometastasis in pathologically negative lymph nodes were tested through immunohistochemical cytokeratin (CK) analysis and the relationship between CK(+) and staging, survival were analyzed.</p><p><b>RESULTS</b>In these 39 patients, the survival of CK(+) and CK(-) patients were 32 months and 48 months respectively (P = 0.0178). Multivariate analysis of Cox regression model showed: clinical stage (P = 0.0288) and relapse or metastasis (P = 0.0053) affected the prognosis while micrometastasis in lymphnodes (P = 0.7740) did not.</p><p><b>CONCLUSION</b>The detection of micrometastasis in the lymphnodes may serve as a supplement to the present staging system for lung cancer. Even though the prognosis of patients with micrometastasis being poorer than those without, micrometastasis in the lymph nodes should not be regarded as an independent prognostic factor.</p>
Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Carcinoma Pulmonar de Células não Pequenas , Diagnóstico , Metabolismo , Queratinas , Metabolismo , Neoplasias Pulmonares , Diagnóstico , Metabolismo , Patologia , Linfonodos , Patologia , Estadiamento de Neoplasias , PrognósticoRESUMO
<p><b>BACKGROUND</b>To detect the expression of human epidermal-growth-factor receptor 4 (HER4) and elucidate the relationship between its overexpression and the clinicopathological characteristics in non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>The expression of HER4 was detected in 70 cases of paraffin-embedded NSCLC tissues by immunohistochemical assay.</p><p><b>RESULTS</b>HER4 were overexpressed in 91.4% of NSCLC. The overexpression of HER4 was significantly related to lymph node metastasis (P=0.007), TNM stages (P=0.011) and postoperative survival rate (P= 0.0258).</p><p><b>CONCLUSIONS</b>erbB4 is one of the genes to regulate the growth of advanced NSCLC. The artificial interference with HER4 overexpression may be a good way in the treatment of advanced NSCLC.</p>