Overview of miRNA involved in PASMCs phenotypic switching in pulmonary hypertension / 中国药理学通报

Pulmonary hypertension ( PH) is occult, with no distinctive clinical manifestations and poor prognosis.Pulmonary vascular remodelling is an important pathological feature in which pulmonary artery smooth muscle cell ( PASMCs) pheno- typic switching plays a crucial role.MicroRNA (miRNA) is a class of evolutionary highly conserved single-stranded small non-coding RNA.Recently, an increasing number of scholars have found that miRNA can play an important role in the occurrence and development of PH by regulating the phenotypic switching of PASMCs, which is expected to be a potential target for the prevention and treatment of PH.It has been found that miR NA such as miR-221 , miR-24, miR-15b, miR-96, miR-23a.miR-9, miR-214, miR-20a can promote the phenotypic switching of PASMCs, while miRNA such as miR-21, miR-132, miR-182, miR-449, miR-206 .miR-124, miR-30c, miR-140.miR-17-92 cluster can inhibit it.This article aims to review the research progress on miRNA that mediates PASMCs phenotypic switching in PH from both growth factor-related miRNA and hy- poxia-related miRNA.

Clinical application and processing of separate movable partial denture / 华西口腔医学杂志

<p><b>OBJECTIVE</b>This report is to introduce the processing method of the separate movable partial denture and get an initial clinical evaluation.</p><p><b>METHODS</b>The separate movable partial denture was developed as a kind of special design in utilizing double base plate to separately get support for bearing stress and get the stability of retention.</p><p><b>RESULTS</b>The clinical application indicated that the separate movable partial denture has effective function of common movable partial denture as well as has a good function of natural human teeth protection, especially for those patients with I -II tooth loose.</p><p><b>CONCLUSION</b>The separate movable partial denture is the ideal choice of treatment for those patients who are suffering I - II teeth loose. This type of movable partial denture was considered effectively protect natural human teeth and extend the lifetime of natural tooth long-term and further observation in clinical care on this type of denture is needed.</p>

The study on color space of the VINTAGE & UNIBOND standard color / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To research the color space of the standard color board, guide the clinic work of color match, and establish an foundation for deeper researching.</p><p><b>METHODS</b>Through taking analysis of reflecting spectrum and spectral tristimulus, each parameter of the color on standard board was found out. The color difference between border upon colors on board was worked out through matching the color parameters. The number of color space between each border upon color on standard color board, divided by deltaE = 1.5, was found.</p><p><b>RESULTS</b>The number of color space between each border upon color was 3-6. The color space was bigger in group B, but smaller in group D. The color space was bigger in high lightness area, but smaller in low lightness area.</p><p><b>CONCLUSION</b>Some color space has been found between standard color borders of VINTAGE and UNIBOND. Color of natural teeth is unable to be completely included into standard color border, especially in clinical care.</p>