Risk of second primary lung cancer in patients with thyroid cancer: a meta-analysis based on big population studies / 中华医学杂志(英文版)

BACKGROUND@#Previous studies have revealed that the number of cancer survivors developing a second primary malignancy is increasing, especially among thyroid cancer patients, and lung cancer is still the main cause of cancer death. Therefore, we aimed to investigate the risk of second primary lung cancer (SPLC) in patients with thyroid cancer.@*METHODS@#We searched the PubMed, Web of Science, Embase, and Scopus databases up to November 24, 2021, for relevant research and merged the standardized incidence ratios (SIRs) and 95% confidence intervals (95% CIs) to evaluate the risk of developing SPLC in patients with thyroid cancer.@*RESULTS@#Fourteen studies involving 1,480,816 cases were included in our meta-analysis. The pooled result demonstrated that thyroid cancer patients may have a higher risk of SPLC than the general population (SIR = 1.21, 95% CI: 1.07-1.36, P  < 0.01, I2  = 81%, P  < 0.01). Subgroup analysis stratified by sex indicated that female patients may have a markedly higher risk of SPLC than male patients (SIR = 1.65, 95% CI: 1.40-1.94, P  < 0.01, I2  = 75%, P  < 0.01).@*CONCLUSIONS@#Thyroid cancer patients are more likely to develop SPLC than the general population, especially women. However, other risk factors must be investigated, and more prospective studies are needed to confirm our results.@*REGISTRATION@#International Prospective Register of Systematic Reviews: No. CRD42021285399.

Significance of liver histopathological examination in diagnosis and treatment of drug-induced liver injury / 临床肝胆病杂志

The incidence rate of drug -induced liver injury (DILI) tends to increase in recent years, and early accurate diagnosis and eval -uation of the degree of liver injury are great challenges in diagnosis and treatment .The pathomorphological features of DILI are determined by the structure and metabolic features of hepatic lobules .The basis of pathological injury pattern is injury of related targets , i.e., hepatocytes,biliary epithelium, and blood vessel endothelium, which determines the distinct features of DILI.Although DILI has various pathological features,it has major injury patterns of acute hepatitis type , chronic hepatitis type, acute cholestatic type, chronic cholestatic type, and cholestatic hepatitis type.The degree of the pathological injury of DILI is associated with the disease severity and prognosis of patients , and pathology helps to identify small bile duct injury and vascular endothelial injury caused by drugs as early as possible .The liver histological features of DILI overlap with other diseases, and related clinical indices should be used to make an objective , accurate, and timely diagnosis of DILI.This article reviews the pathomorphological features and patterns of DILI and elaborates on the significance of liver histological examination in the diagnosis and treatment of DILI.