Estudio de factores genéticos en la agregación familiar de la esquizofrenia en Santiago, Chile / Genetic factors study in family aggregation of schizophrenia in Santiago, Chile

Forty four randomly selected schizophrenic probands, 22 female, aged 28 to 48 years old, were studied. From them, an extensive genealogic reconstruction was performed. Probands and relatives were interviewed using the structured interview CIDI and DSM-III-R check list. Schizophrenia was diagnosed using DSM-III-R criteria. Complex segregation analysis was done using Pointer program. The hypothesis of a multifactorial inheritance, without the participation of major genes, could not be rejected. Likewise, the major dominant and co-dominant gene forms of transmission could not be rejected. Our results show the participation of a major dominant locus and a multifactorial component in the inheritance of schizophrenia, as has been reported elesewhere

Validez del CIDI para el diagnóstico de esquizofrenia / Assessment of CIDI for schyzophrenia diagnosis

Se analiza la utilidad del CIDI para estudios epidemiológicos en poblaciones. Su rendimiento es menor en esquizofrenia en comparación con el diagnóstico clínico

Encuesta sobre el uso de psicofármacos en pacientes internados en un hospital universitario de adultos / Use of psychotropic drugs in patients admitted to a university hospital for adults

We performed a survey concerning the use of psychotropic drugs among 223 patients admitted to a university hospital in november 1986. 39% of patients were receiving some psychotropic drug, and 73% of these corresponded to benzodiazepines. Insomnia and anxiety were reported as the main causes for drug use. Patients above age 50 were most affected. 61% of drugs had been in use for more than 6 months. These results confirm previous findings regarding psychotropic drug use in adults