Pyoderma gangrenosum associated to the use of cocaine/levamisole. Series of three cases and literature review

Abstract Pyoderma gangrenosum associated to the use of cocaine/levamisole is a rare condition associated to their consumption. Cocaine use is frequent in Colombia, and the substance is contaminated with levamisole, an anthelmintic that increases the psychotropic effects and enhances its side effects. We present three clinical cases of patients with ulcerated lesions, in which the diagnosis was pyoderma gangrenosum secondary to the use of cocaine contaminated with levamisole. This called the attention of the health staff to investigate the abuse of substances in gangrenous pyoderma and also evidence that the interruption of consumption was the basis of management.

Hallazgos histopatológicos en biopsias de cérvix de pacientes con diagnóstico citológico de atipia de células escamosas de significado indeterminado / Histopathological findings in cervical biopsies from patients with cytological diagnosis of atypical squamous cells of undetermined significance

Introducción: la atipia de células escamosas de significado indeterminado se refiere a cambios citológicos sugestivos de lesión intraepitelial de bajo grado, pero insuficientes para una interpretación definitiva. En nuestro medio, no se conoce la frecuencia de lesiones displásicas en pacientes con atipia de células escamosas de significado indeterminado y no hay certeza de cuál es el abordaje clínico más adecuado. Objetivo: describir los hallazgos histopatológicos en las biopsias o conizaciones realizadas por atipia de células escamosas de significado indeterminado y determinar la necesidad de toma de biopsia en estas pacientes...

Introduction: The term atypical squamous cells of undetermined significance refers to cytological changes suggestive of low-grade intraepithelial lesion that are insufficient for a definitive interpretation. In our region, there are no studies evaluating the frequency of dysplastic lesions in patients with atypical squamous cells of undetermined significance and there is no certainty about the most appropriate management. Aim: To describe the histopathological findings in biopsies or conizations performed after a diagnosis of atypical squamous cells of undetermined significance was made on cytology, and to determine the need for biopsy in these patients...