Analysis of drug therapy in a patient with pulmonary infection secondary to suppurative thrombophlebitis / 药学实践杂志

Objective To explore the role of pharmaceutical care in the treatment of patients with pulmonary infection secondary to suppurative thrombophlebitis. Methods The treatment of a patient diagnosed with pulmonary metastatic infection secondary to suppurative thrombophlebitis and the whole process of clinical pharmacists participating in the monitoring were analyzed retrospectively. The use of antibiotics was evaluated, and the experience of coagulation management in suppurative thrombophlebitis was explored. Results Based on the infection site, characteristics of septic thrombus, monitoring of vancomycin blood concentration, pharmacokinetics and pharmacodynamics characteristics of antibiotics, clinical pharmacists provided comprehensive pharmaceutical services for clinicians and patients in terms of anti-infection scheme adjustment, optimization of vancomycin individualized treatment, anticoagulant timing. Patient’s systemic infection and septic thrombus can be effectively controlled and which promotes the treatment of patients with suppurative thrombophlebitis. Conclusion Clinical pharmacists can play an important role in the treatment team of severe patients to improve the rational use of antibiotics.

302 cases of adverse drug reaction reports / 药学实践杂志

Objective To study the features,general patterns and predisposing factors of adverse drug reactions(ADR) occurred in our hospital and to provide the guidance for rational and safe use of drugs in clinic.Methods 302 cases of ADR were reported from September 2015 to September 2017 in our hospital.Age distribution,gender,route of administration,drug categories,systems or organs involved,clinical manifestations,adverse reaction types involved in ADRs were analyzed retro-spectively.Results Among the 302 ADR reports,137 cases are male patients(accounting for 45.4%)and 165 cases were fe-male patients(accounting for 54.6%).27.8% of ADR was related to anti-infective agents.70.2% of ADR came from oral ad-ministration and 24.8% ADR was due to intravenous administration.The main clinical manifestations of ADR were lesion of skin and its appendants(61.6%)and followed by the digestive system injury(15.9%).Conclusion The multiple factors may lead to high frequency of ADR.In order to promote rational drug use and reduce the occurrence of ADR,clinicians should pay attention to the ADR monitoring and strictly follow the clinical indications of medications.

Activation of α7 nicotinic acetylcholine receptor alleviates cerebral cortical neuron injury induced by oxygen- glucose deprivation / 第二军医大学学报

Objective To investigate the effect of activatinga7 nicotinic acetylcholine receptor (α7nAchR) on cerebral cortical neurons injury induced by oxygen-glucose deprivation (OGD) and the possible mechanism. Methods Cerebral cortical neurons cultured for 7 d were randomly divided into three groups; control group, OGD group (Cells experienced a 12 h oxygen- glucose deprivation) and OGD group treated with PNU-282987 (Cells experienced a 12 h oxygen-glucose deprivation with PNU- 282987 pretreatment for 24 h). Cell viability was determined by CCK-8 assay, lactate dehydrogenase (LDH) was examined to reflect cell injury, apoptosis and reactive oxygen species (ROS) production were analyzed by flow cytometry, and expression of hemeoxygenase-1 (HO-1) and hypoxia inducible factor-1a (HIF-1a) were detected by Western blotting analysis. Results OGD resulted in cell death, LDH increase, and cell apoptosis. Compared with the OGD group, PNU-282987 pretreated group had significantly increased cell survival (P α protein expression was significantly reduced in PNU-282987 pretreated group compared with the OGD group (Pα7nAchR can protect cerebral cortical neurons against OGD-induced injury, which may be related to the anti-oxidative stress.