RESUMO
Platelet-aggregation receptor 1 (PEAR1) is a transmembrane receptor identified in 2005 and expressed mainly on platelets and endothelial cells. PEAR1 is a receptor protein that contacts platelets with each other and plays an important role in platelet activation and aggregation. Endothelial cells play an important role in maintaining vascular tone and vascular repair, and PEAR1 regulates the process of tumourigenesis and development by affecting their proliferation and associated neovascularisation. In recent years, PEAR1 has gradually been recognized as a potential target for antithrombotic drugs. This review focuses on elucidating the mechanisms of platelet endothelial aggregation receptor 1 and related signaling pathways in platelets and endothelial cells, and provides new ideas for the study of drug therapy for tumour-associated thrombosis.
RESUMO
Sleep disorders are one of the important problems affecting children′s growth and development and growth health.Nearly half of children in China have sleep disorders symptoms, and the number is still rising.In recent years, a large number of data have shown that the level of vitamin D in sleep disorders children is significantly lower than that of healthy children with the same age, which indicates that vitamin D deficiency may be one of the causes of sleep disorders.In this paper, the relationship between sleep disorders and vitamin D deficiency and the mechanisms of vitamin D participation in sleep disorders are reviewed.
RESUMO
Sexual health is an important part of the overall health of patients.The ability of nurses to carry out sexual health care directly affects the overall level of medical care. This article reviews the concepts of sexual health and sexual health care, the evaluation tools of sexual health care, the practical models and influencing factors of nurses' sexual health care, with a view to providing a reference for improving the practice level of nurses carrying out sexual health care.