Effects of prolonged administration of large doses of ACTH on bufo melanostictus tadpoles

The present study reports the effects of different ACTH preparations, in similar and different concentrations on Bofo Melanostictus Tadpoles. ACTH administration proved antagonistic to tadpole growth hormone. There seemed to be no dose-effect response when ACTH was administered in 0.02 IU/ml instead of 0.01 IU/ml. Similar ACTH concentrations with difference of manufacture showed varied biological potency. This perhaps indicates loss of effectiveness due to change from ACTH 1-24 to ACTH 1-18 to ACTH 1-10 in descending order

effects of mefenamic Acid on the osmotic fragility of lacertilian erythrocytes

Osmotic fragility of red cells is increased by the use of mefenamic acid. The use of this analgesic induces hemolytic anemia. Study of osmotic f agility of RBCs of control and test was observed following administration of 7.1 mg, 10.5 mg and 14 mg/day mefenamic acid to each lizard. Increased osmotic fragility was observed with increase in the amount of dose on day 6 and day 12

effects acetylsalicylic acid on the pituitary prolactin of the lizard, uromastix hardwickii

This study deals with the intravenous administration of 7mg acetylsalicylic acid [ASA] solution to Uromastix hardwickii for 4 days. It enhances the activity of anterior pituitary lactotrophs, when 0.1 ml of pituitary homogenate of ASA treated was injected hypodermically to crop- sac showed a greater diametric response and increased activity with milk like secretion than that of the injections of 0.1 ml homogenate of control pituitary. The present study indicated that ASA induces hyperprolactinemia

effects of isoniazid on the osmotic resistance of lacertilian erythrocytes

Osmotic fragility of erythrocytes is increased by a number of commonly used analgesics, antimicrobial and antimalarial drugs, resulting in drug-induced hemolytic anemia. Study of erythrocyte osmotic fragility of control and test blood was determined after 5,10 and 15 days of 0.06 mg/ml/day Isoniazid [INH] administration to test subjects. Isoniazid treated subjects exhibited greater RBC fragility than control in 0.1 to 0.3 hypotonic solutions. Control subjects exhibited only 3 per cent destruction in 0.4 per cent saline; whereas test subjects exhibited 12 and 11 per cent destruction on day 5, and 15 in 0.4 per cent concentration of saline, while 10,13 and 15 per cent destruction in 0.5 per cent saline. The study indicated that following prolonged administration of Isoniazid a great number of osmotically fragile RBCs enter the blood stream