Bilateral Pleural Effusion Possibly Related to Amantadine

We describe a 73-year-old Parkinson's disease patient with bilateral pleural effusion after receiving a prescription of L-dopa and amantadine. Although, the mechanism is unknown, the occurrence of bilateral pleural effusion following the administration of amantadine and improvement after the cessation of amantadine suggests a possible relationship between amantadine and pleural effusion.