RESUMO
Background: Acacia catechu has been widely used in Ayurveda for treating many diseases. Its heartwoodextract is used in asthma, cough, bronchitis, colic, diarrhea, dysentery, boils, skin afflictions, sores and forstomatitis. The decoction of heartwood is used for drinking purpose in southern part of India especiallyin Kerala.Objective: The current study was carried out to evaluate immunomodulatory effects of heartwood extracts of A. catechu in Swiss albino mice.Material and methods: In vivo immunomodulatory activity was analyzed by hemagglutinating antibody(HA) titer, plaque forming cell assay and delayed type hypersensitivity (DTH). In vitro immunomodulatory potential of the extracts was studied using peritoneal macrophages and splenocytes from mice.Effect of extracts on phagocytic activity of macrophages was analyzed by nitroblue tetrazolium (NBT)reduction assay and cellular lysosomal enzyme assay. Anti-inflammatory activity was studied by nitricoxide (NO) assay and production of TNF-a and IL-10.Results: A dose dependent increase in antibody titer was observed with extracts treatment. Treatmentwith extracts produced an enhancement in the number of antibody producing cells in the spleen. DTHreaction was significantly decreased with extracts treatment. An increased phagocytic response wasshown by peritoneal macrophages on treatment with the extracts as evidenced by its effect on NBTreduction and cellular lysosomal enzyme activity. The extracts inhibited the release of pro-inflammatorycytokine TNF-a and the production of NO. IL-10 production was significantly increased after extracttreatment.Conclusion: The results of the present study indicate the immunomodulatory effects of A. catechu extracts on humoral, cell mediated and non-specific immune functions.© 2017 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Publishing Services byElsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
RESUMO
Objetivo: Determinar a prevalência, severidade e características da cárie precoce na infância em Crianças de 3 a 6 Anos de idade de Mysore, India. Método: Dez pré-escolas, cinco públicas e cinco privadas foram aleatoriamente selecionadas de cinco diferentes áreas da cidade de Mysore. Um total de 500 crianças e seus pais/responsáveis foram incluídas no estudo. A ocorrência de cárie precoce na infância foi diagnosticada com o uso dos critérios NIDCR. A existência de cárie dentária foi feita com o uso dos índices ceo-d e ceo-s.Resultados: A prevalência de cárie precoce foi de 56,6% com um ceo-d e ceo-s médios de 2,20 e 2,97, respectivamente. Do total de crianças, 56% dos meninos e 57,1 % das meninas estavam afetadas. Não se verificou diferença na prevalência de cárie entre os estudantes da rede pública e privada. Cerca de 94,84% do total do ceo-d envolvia o componente cariado. O arco superior foi mais afetado (29,32%) do que o inferior (26,14%). As superfícies oclusais foram as mais afetadas (46%) e as menos afetadas foram as superfícies lisas (16%). Os molares inferiores foram os mais acometidos (39,42%) e os incisivos inferiores os menos afetados (1,84%). Conclusão: O aconselhamento oral deve ser iniciado aos seis meses quando da erupção dos primeiros dentes decíduos.
Objective: To determine Early Childhood Caries (ECC) prevalence, severity and pattern in preschool children of Mysore City, Karnataka. Methods: A total of 10 preschools, five government and five private were selected randomly from 5 different sectors in Mysore. A total of 500 children and their parents were included in the study. Early Childhood caries was diagnosed using NIDCR definition. Dental caries status was recorded using dmft and dmfs indices. Results: The results show that early childhood caries prevalence in 3-6 year old preschool children was 56.6% with a mean dmft and dmfs of 2.20 and 2.97 respectively. Out of the 500 children, 56% males and 57.1 % females were affected .There was no difference in caries prevalence between children of government and private preschools. 94.84% of total dmf was comprised of decayed component. Maxillary arch was affected more (29.32%) than the mandibular arch (26.14%).The most affected surfaces were the occlusal surfaces (46%) and least affected were the smooth surfaces (16%). Mandibular posteriors were affected the most (39.42%) and lower incisors were the least affected (1.84%). Conclusion: The results support the view that oral counseling should begin within 6 months of eruption of 1st primary tooth.