[Nonsyndromic deafness-the segregation analysis]

The hearing loss is a problems of public health which can be described as major from the economic and human point of view, since 1 child over 1000 has at the birth a severe or profound deafness. This deafness has a prevalence of 1 per 10 in certain Tunisian geographical isolates. Our work concerned 33 patients with nonsyndromic sensorineural deafness who are regarded as probands and are recruited in service ORL of the Hospital La Rabta of Tunis. For each patient, a family investigation was carried out in residence and complete pedigrees were established. In addition, we selected a sample of 320 unaffected subjects for whom we established pedigrees in order to compare their inbreeding coefficient with that of the patients The samples of this study are orginated from the governorate of Bizerte The segregation analysis by the method of the maximum likelihood applied to the sample of deafs allowed to estimate the segregation frequency by taking account of various modes of selection in the sibships. The results obtained are compatible with autosomic recessive model with complete penetrance of the gene. The recessive hypothesis is strenghthened by the increase in the inbreeding coefficient of the probands compared to that of the controls

Contribution a une etude epidemiologique de l'otospongiose dans le gouvernorat de Nabeul

The incidence of otospongiosis is high, in the delegation of NabeuI, Dar Chaabaneand Hammamet These zones seem to be the homes of origin of this disease.The expression of otospongiosis is variable according to age and sex. The maximal period of risk is between 26 and 35 years in woman, and begins until 35 years in men. The cumlated incidence is 2,9% in women, and 1,3% in man. This female predominance was tied up on endocrinis factors, and had not been due to genetic transmission then, the analysis of familial data suggested the existance of genetic constituant in the etiology