[ sarcoidosis]

Sarcoidosis is a multisystemic granulomatosis seen mainly in the young adult. This is a retrospective study which evaluated 35 cases of sarcoidosis confirmed histologically, during periods from 1985 to 1999. In this study, 88.57% of patients were female with a mean age of 47.5 years old. The main complaint was often a peripheral node lesion followed by an ocular lesion. This clinical study had a very polymorphic presentation. The endothoracic lesions were largely predominant [94.28%], followed by extra thoracic lesions such as cutaneous lesions [big nodules and erythema nodosum], ocular lesions [25.7%], represented by anterior uveitis [4 cases], posterior uveitis [2 cases] and one case of panuveitis. Lymphatic node lesions were present in 63% of cases. The articular involvement was mainly made of inflammatory arthralgia. The bone lesions seen in 5 cases were made of sarcoid dactylitis confirmed histologically in 3 cases. We observed one case of sarcoidosis associated to spondylarthropathy. Prednisone was indicated in 27 patients at a dose of 0.5 to 1mg/kg/day, leading to a good recovery in 58.33 of cases. The mean follow-up was 20 months. Sarcoidosis in Morocco seems to be rare. The association of sarcoidosis and spondylarthropathy was rarely described. Posterior uveitis was present in this series

[Kikuchi disease and systemic lupus erythematosus]

Kikuchi's disease or histiocytic necrotizing lymphadenitis is a rare anatomico-clinical entity affecting young females. It is clinically manifested by generalized lymphadenopathy, fever and neutropenia. Diagnosis depends on histological examination. The etiology is not well known yet, although an autoimmune hypothesis has been suggested. It may be associated with systemic lupus erythematosus. The authors reported a case of Kikuchi's disease associated with apparition of secondary systemic lupus erythematosus. It is about a 16 years old woman who presented with fever, generalized lymphadenopathy, inflammatory polyarthritis and myalgia. Laboratory tests revealed an important inflammatory syndrome with leucopenia. Immunological test were normal and lymph node biopsy was in favour of necrotizing histiocytic lymphadenitis. [Kikuchi disease]. Later on after one year lupus disease was finally identified. Kikuchi's disease is a rare less frequent benign condition, the clinical symptoms resolve spontaneously but a regular Follow up should be taken with these patients to detect secondary onset of another autoimmune disease especially the systemic lupus erythematosus