[ case report of gastrointestinal bleeding due to gastric lipoma]

Benign Gastric tumors are rare and generally account for less than 10% of all stomach tumors. Gastric lipoma is a rare tumor that constitutes approximately 3% of all benign tumors of the stomach and mainly is seen as a submucosal mass. Most gastric lipoma are asymptomatic and are found accidentally. Occasionally they can cause symptoms such as gastrointestinal bleeding, obstruction, abdominal pain and intussuception. CT scan and endoscopy are helpful in diagnosis. The main modality of treatment is surgery. Diagnosis is confirmed by histology. In this article, a patient with weakness, fatigue, and melena complaints is presented. On gastric endoscopy a yellowish submucosal mass was seen in antrum. Abdominal CT scan disclosed a mass with fat density resembling lipoma. The patient underwent surgery and diagnosis of lipoma was confirmed by histology. Although gastric lipoma is rare, it should be considered in the assessment and differential diagnosis of hemorrhagic submucosal masses in the stomach

Lipid peroxidation inhibition, superoxide anion and nitric oxide radical scavenging properties of thymus daenensis and anethum graveolens essential oils

Safety and efficacy of the synthetic antioxidants used in the food industry are frequently questioned because such antioxidants are unstable and highly volatile, therefore, interest in finding naturally occurring antioxidants that have the potential to protect human beings from damage induced by oxidative stress has intensified. Bioactivities of Thymus daenensis and Anethum graveolens essential oils with special reference to their antioxidative properties are studied. Total phenolic content [TPC], lipid peroxidation inhibition [LPI], ferrous-ion chelating [FIC], superoxide anion and nitric oxide radical scavenging, and tyrosinase inhibition activities of the essential oils were determined. TPC of T. daenensis and A. graveolens oils were 644.07 +/- 6.79 and 174.91 +/- 2.05 mg GAE/100 g. T. daenensis and A. graveolens oils showed the highest LPI activity with FICs of 63.28 +/- 0.21 and 70.22 +/- 1.9 percent respectively. Superoxide anion and nitric oxide radical scavenging activities of the above oils had IC[50] of 0.013, 0.001 and 0.005, 0.0014 mg, respectively. A. graveolens oil showed 6 fold higher anti - tyrosinase activity than T. daenensis oil. There was not correlation between lipid peroxidation or ferrous ion chelating activities with total phenolics implying that the oils contain chelating ligands. The effects of antioxidant phytochemicals in the biological systems are ascribed on their ability to scavenge radicals, chelating metals, activate the antioxidant enzymes, and to inhibit the oxidases. T. daenensis and A. graveolens oils have good commercial potential in both food processing and cosmetic industries

Chlamydia trachomatis and cervical intraepithelial neoplasia in married women in a Middle Eastern community

The objective of this study was to determine the association between vaginal Chlamydia infection and cervical intraepithelial neoplasia [CIN]. Data were collected in a case-control study for 60 patients with CIN in biopsy and 85 control subjects with normal colposcopy and biopsy. Serum antibodies to C. trachomatis were associated with an increased risk for CIN [odds ratio [OR] = 7.3; 95% confidence interval [CI] 1.5-35.2]]. There was also a significant association between presence of inclusion bodies for C. trachomatis and CIN [OR = 5.5; 95% CI 2.4-12.4]. These results indicate a strong association between CIN and chlamydial cervicitis

[Antibiotic-resistance patterns of helicobacter pylori isolates obtained from patients in Kerman- 2009]

Background and Aims: Based on serological studies the prevalence of Helicobacter Pylori infection in Iranian adults is up to 80%. Gastritis, peptic ulcer and gastric adenocarcinoma are common clinical outcomes of this infection in Iran. Since antibiotic resistance patterns of Helicobacter pylori are different geographically, local studies are highly required

Method: From April to December 2009, 63 isolates of Helicobacter pylori were obtained From 191 patients referred to the endoscopy unit of Afzalipour hospital in Kerman. Demographic features including age, gender, symptoms, were recorded before the sampling and sensitivity to six common antibiotics used for the treatment of H.pylori infection was determined. Modified disk diffusion test was used to evaluate antibiotic resistance pattern. Data analysis was done through SPSS 16 and using Pearson chi-square test

Results: The patterns of antibiotics resistance were as below: metronidazole 55.5%, clarithromycin 30.1%, tetracycline 3.1%, amoxicillin 26.9%, ciprofloxacin 7.9% and no resistance to furazolidone was detected. While 12.7% of the isolates were susceptible to all the six antibiotics, 55.6% were resistant to one antibiotic, 25.4% to two antibiotics, 6.3% to three antibiotics and there was no resistance to more than three antibiotics at the same time

Conclusion: According to the obtained antibiotic resistance rates in this study, performing antibiogram tests before starting the treatment is necessary

[Report of a case with obscure GI bleeding in extramural pedunculated GIST]

Obscure gastrointestinal [GI] bleeding is defined when the source of GI bleeding could not be determined by upper endoscopy, colonoscopy or barium small bowel transit. In this report, a 41 year-old man presented with a history of over ten recurrent episodes of melena since four years prior to admission. The source of bleeding was not detected by multiple upper and lower GI endoscopies. During the last admission, other investigations which included small bowel transit, abdominal radioisotope scan and double balloon enteroscopy up to the mid-jejunum were all inconclusive. For more evaluation, an exploratory laparatomy and intra-operative endoscopy were planned. On laparatomy, a tumoral mass of 7 cm diameter was found on the inferior aspect of the stomach. The tumor was attached to the gastric wall by a 2 cm pedicle and connected into the gastric lumen via a small orifice which was not visible on endoscopic view. The tumor was resected with the surrounding gastric wall. Pathologic report favored pedunculated gastrointestinal stromal tumor [GIST] and confirmed with the positive CD117 antigen. Therefore, in the approach of patients with obscure GI bleeding, rare causes such as extramural pedunculated GIST should be considered

[Studying the epidemiology of traumatic patients referring to Valie-Asr hospital in Arak]

Nowadays, trauma has considered as one of the important cause of mortality and disability in different countries. Due to identify the importance of this problem spread, it is vital to plan some strategies in each region in order to prevent and decrease trauma. Therefore, the aim of this study was the epidemiological assessment of traumatic patients referring to Arak Valie-Asr Hospital in 2006. In this cross-sectional and descriptive study, the data of 813 traumatic patients, who were admitted to the Arak Valie-Asr Hospital in 2006, were extracted by hospital trauma database. The data were such as: demographic variables, location of trauma and its type, type of trauma [blunt or penetrating], smoking or taking drugs, using safety belt in car accidents, and how to transfer patients to the hospital. According to the findings: the most common cause of trauma was car accidents [351, 43%] followed by occupational accidents [171.21%]; 74% of patients were males; 53% were between 20-44 age-group and 64% didn't get diploma. Most of traumas have occurred outside of the town [704, 87%]; 609 patients [69%] had been transferred to the hospital by people; about 693 [85%] of traumas were blunt type. In car accidents, 16 patients [5%] were smoking and 6 patients [2%] using narcotics. Only 64 patients [18%] had used safety belt. The agents of accidents were as follow: about 57% car vehicle [200]; 18% human [65] and also 25% objects and obstacles [86]. The present findings showed like other studies, the most common cause of trauma in the mentioned hospital was car accidents and most young meals are at high risk. The second cause was occupational accidents. Traumas and accidents injuries are one of the serious challenges of public health. Hence, training and developing culture for the use of safety belt, helmet and also safety measures at work could be the most important preventive factors

[Pancreatobiliary cancers in Iran: a population- based study]

Our knowledge regarding the epidemiology of pancreatobiliary cancers in Iran is limited. This study presents the first population-based report on pancreatobiliary cancers performed in five provinces of Iran. Data used in this study were retrieved from population-based cancer registries in five provinces of Iran [Gilan, Mazandaran, Golestan, Ardabil and Kerman] from 1996 to 2000. Crude incidence rate, age standardized incidence rate [ASR] and age specific incidence rate were calculated for each cancer sites using the direct method. Overall ASR of pancreatic cancer in five provinces was 1.18 and 0.84 per 100, 000 person-years for men and women, respectively. These values for gallbladder and biliary tract cancers were 0.42 and 0.27 per 100, 000 person-years for men and 0.93 and 0.22 per 100, 000 person-years for women, respectively. ASR of pancreatobiliary cancer is low in Iran compared to western countries

[Demographic and clinical features of ulcerative colitis patients in Kerman city during 2005-2007]

Ulcerative colitis is one of the inflammatory bowel diseases with unknown etiology. Genetic and environmental factors are thought to be effective in this disease. According to the limited studies in our country, general assessment of demographic features and clinical symptoms seems to be essential. In this prospective and cross-sectional study, 85 cases of ulcerative colitis referred to the 3 gastroenterologist offices in Kerman city were evaluated during 2005-2007. The diagnosis was confirmed based on clinical features, colonoscopy, pathology and ruling out of other causes. Data were collected through direct interview and analyzed by SPSS 15 software. Mean age at the time of diagnosis was 33.31 +/- 13.12. Duration of symptoms onset until diagnosis was 8 months. Male to female ratio was 0.8/1 and the most important clinical manifestations were rectorhagia and bloody diarrhea [92.9%], abdominal pain [20%], mucoid diarrhea [13.1%], weight loss [11.2%] and fever [4.4%]. The pattern of disease was chronic intermittent in 83.5%, chronic continuous in 13% and acute self-limited in 3.5%. Anatomically disease was limited to the rectum [8.3%], recto sigmoid [23.5%], recto sigmoid and descending colon [28.5%], transverse colon [21.2%] and pan colitis. [18.8%]. Extra intestinal manifestations were seen in 22.35% of cases of whom 12.96% had oral involvement, 5.85% had hepatic involvement and 3.53% had musculoskeletal involvement. Recurrent inflammatory bowel disease is one of the important reasons of referral to gastroenterologists. Ulcerative coilitis in Kerman is similar to other countries of world epidemiologically, demographically and clinically but its seems that severe clinical courses, extra intestinal manifestations and second old age peak to be less comparing to other studies

first population-based Cancer survey in Kerman province of Iran

Cancer is the second most common cause of non-accidental death in Iran. Geographical, racial and habitual differences have led to the variation in the incidence of cancer in different regions of this country. This study was performed to determine the incidence of cancer in the Kerman Province, central Iran. All newly diagnosed cases of cancer in the Kerman Province were recorded in a five-year period [1996-2000]. In all, 5884 new cases [55.7% males] of cancer were found after elimination of repeated cases. Based on age-standardized incidence rates [ASR] the most common cancers in men were stomach [10.2], lung [7.1], bladder [6.7], colorectal [5.9] and non-Hodgkin's lymphoma [5.8], while in women the most common cancers were breast [16.9] colorectal [5.9], stomach [5.1], leukaemia [4.6] and non-Hodgkin's lymphoma [2.8]. For all cancers, ASR was 76 for males and 68 for females. The results indicate that upper gastrointestinal cancer, especially oesophageal cancer is very rare in central Iran in contrast to northern Iran, although these types of cancers are some of the most common cancers in the Kerman Province

Creatinine, blood urea nitrogen and thyroid hormone levels before and after haemodialysis

A study was carried out on 57 patients with chronic renal failure in a hospital in Kerman city, Islamic Republic of Iran. Blood samples were taken before and after haemodialysis to measure blood urea nitrogen and serum creatinine, triiodothyronine [T3] and thyroxine [T4] levels. Findings revealed that before dialysis T4 in 11 cases and T3 in 29 cases were lower than the normal range, but after haemodialysis only 3 cases for T4 and 15 cases for T3 were lower than normal levels. The remaining cases reverted to normal state. We suggest that a feedback relationship exists between the major end catabolic products [creatinine and blood urea nitrogen] and thyroid hormone serum levels

[ incidence rate of gastrointestinal tract cancers in Kerman province during 1996-2000]

Cancer as the second leading cause of death following cardiovascular diseases has always been a threat to human life and due to its peculiar nature and lack of a favorable treatment, it is considered as a research priority in all communities. Understanding the geographical distribution of the incidence of various tumors, constitutes the first step in health and treatment planning. This study was carried out to review the incidence rate of gastrointestinal cancers in Kerman province and estimate disease load in this geographical area. Through a community-based registration system, all the documents related to cancer diagnosis in Kerman province from 1996 to 2000 were investigated. Among 5867 registered cases of cancer with an average age of 51.5 +/- 20.6 years, men composed 55.5% and women 44.5% of the cases and 1303 ones [22.2%] had gastrointestinal tract cancers among them gastric tumors [39%] had the highest incidence rate. Following gastric tumors, tumors of colon [29.4%], esophagus [12.5%], liver [5.83%] gallbladder [5.3%], and pancreas [2.84%] acquired the next ranks in regard to the incidence rate. The incidence pattern of aforementioned cancers in men showed the same pattern as the general population, but in women, colon tumors with the incidence rate of 35% have the highest incidence rate while tumors of the stomach [29.71%], esophagus [10.15%], gallbladder [9.8%], liver [5.26%] and pancreas [4.32%] were the next. Although, various GI malignancies have a lower incidence rate in Kerman province compared with other countries, the fact that these malignancies account for 22.4% of all malignancies, greatly enhances the need for serious planning for prevention, early diagnosis and correction of improper dietary habbits in this province. Moreover development of a versatile cancer registration system to evaluate the domestic comparisons seems essential

Behcet disease: clinical spectrum and association with hepatitis B and C viruses

We studied 48 patients with Behcet disease to determine the clinical spectrum of the disease. We also compared the seropositivity of patients for hepatitis B [HBV] and C [HCV] infection with a healthy control group to.determine whether there is an association. The major physical findings were oral aphthosis 93.8%, genital aphthosis 77.1% and ocular manifestations 64.6%. No patients were HCV antibody seropositive, but 3 of the control group [3.1%] tested seropositive. One patient [2.1%] and 2 in the control group [2.1%] tested positive for both HBV surface antigen and HBV core antibody. The differences were not statistically significant. There is, therefore, no case for recommending viral screening for HBV and HCV in Behcet disease patients at present