[Relationship between cyclosporine blood level and CMV infection during the first 3 months after kidney transplantation]

Organ transplantation is revolutionized since production of cyclosporine. Considering the increased incidence of cytomegalovirus [CMV] infection in patients with transplantation, this study is designed to evaluate the relationship between cyclosporine blood level in patients undergone kidney's transplantation and the rate of CMV infection. This retrospective descriptive study evaluated 511 kidny's transplanted patients for cyclosporine blood level and rate of CMV infection during 100 postoperative days in Labbafinejad hospital [2001-2003]. 57 [11%] out of 511 developed CMV infection. The minimum interval between surgery and infection was 20 days, the maximum interval was 99 days with a mean of 56 days. Mean blood cyclosporine levels in infected and non-infected patients were 383.3 and 310 ng/ml respectively. This difference was statistically significant [p<0.05]. We conclude that CMV infection is closely related to cyclosporine blood level. In order to obtain more efficacy and less cytomegalovirus infections, careful cyclosporine blood level monitoring [<300 ng/ml] is recommended

Age of onset of breast cancer among Iranian women

The age of onset of breast cancer in 1888 women in Iran for the years 1989 to 1994 was compared to that of 6000 cases reported from the U.S. for the years 1916 to 1966 .Despite inherent analytical limitations, it seems that cancer of the breast does occur at a younger age among Iranian woman