RESUMO
Introduction: Irisin is a myokine released from a membrane protein FNDC5 and has positive effects on metabolism. The aim of this study was to compare the effect of high intensity endurance training [HIET] and resistance training [RT] on serum irisin and the insulin resistance index in male rats
Materials and Methods: Twenty-four male rats were randomly divided into the high intensity endurance training [HIET], resistance training [RT] and control groups HIET was conducted on a treadmill for 10 weeks, while RT consisted of climbing a ladder carrying a load suspended from the tail. After 10 weeks of training, serum concentration of irisin, glucose and insulin were measured
Results: Irisin serum levels increased significantly following 10 weeks of HIET, compared with RT [P=0.008]. Glucose levels [P=0.001] and insulin resistance index [P=0.009] in the HIET group were significantly lower than the RT group and the control group as well [P=0.001]. In addition, high intensity endurance training decreased the body weight of the HIET group significantly [P=0.008]. Also, Irisin was found to have a significant negative correlation with glucose and insulin resistance index, whereas no significant relationship was seen between irisin and insulin
Conclusion: Compared to resistance training, HIET is more effective in increasing irisin and the decreasing glucose and the insulin resistance index