effect of butyric acid with autogenous omental graft on healing of experimental achilles tendon injury in rabbits

In this study, the role of local injection of butyric acid [BA] with autogenous omental graft was evaluated in healing of experimental Achilles tendon injury in rabbits. Nine adult male New Zealand rabbits were anesthetized and a partial thickness tenotomy was created on both hindlimbs. In treated group, omental graft was secured in place using BA soaked polygalactin 910 suture. In control group, the graft was sutured without BA. Butyric acid and normal saline were injected daily to treatment and control groups for three days, respectively. Based on the findings, on day 15 after injury, the tendon sections showed that healing rate in BA treated group was higher than that in control group. Furthermore, at days 28 and 45, comparison between BA treated and control groups demonstrated that BA increased the healing rate but with no significance. In summary, results of this study show that application of BA with autogenous omental graft can improve healing process of damaged Achilles tendon

[Related of knowledge and attitude with medication control of tuberculosis patients reffering to ahwaz anti T.B center]

Although directly observed treatment [DOT] strategy had decreased TB mortality, but, in developing countries, TB is yet the leading cause of preventable deaths. The most important reason for inefficiency of treatment is noncompliance on the part of the patient, That it caused not only increasing of probability of recurrence and multi drug resistance, but also formation of prejudicial personal, social, psychological and economical effects. This was a descriptive- analytical study that carried out to assess quality of adherence to tuberculosis drug regimen and its relation to knowledge and attitude factors in patient's reffered to health centers of Ahwaz. The sample size included 167 patients in course of TB treatment that selected randomly and based on aim. A questionnaire, observation, sputum smear, potts - cozart test [for detect of isoniazide metabolites in urine] was used to data collection. Reability of questionnaire was determined by alpha-cronbach correlation method [alpha=0.81]. Showed that 52.7 percent of patient had good adherence to drug regimen, 35.3% had midscore adherence and 12% had poor. In the case of relation between adherence and knowledge and attitude factors showed that statistical meaningful relation found between adherence and knowledge [P=0.017], attitude [P=0.0001]. Results showed that some factors such as cognition, attitude were effective on quality of adherence. It seems that it is required to containing a compiled and continious education for patients in treatment protocols. This is resulted in increasing of knowledge of patients and their family and promote of their attitude about disease and treatment

Fatal sepsis by Bacillus circulam in an immunocompromised patient

An immunosuppressed man was admitted to hospital with diarrhea and a history of urinary tract infection. He was subjected to treatment with antibiotics. The patient died of putative severe sepsis. The etiological agent was a carbapenemase producing isolate of Bacillus circulans with resistance to all prescribed antimicrobial agents

Phospholipase C in Beijing strains of mycobacterium tuberculosis

Phospholipase of Mycobacterium tuberculosis plays an important role in pathogenesis through breaking up phospholipids and production of diacylglycerol. In this study, we examined the Beijing strains of Mycobacterium tuberculosis isolated from Iranian patients for the genes encoding this enzyme. DNA extraction was performed using CTAB [cetyltrimethylammonium bromide] from positive culture specimens in tuberculosis patients. PCR was then used to amplify the plcA, plcB, plcC genes of Beijing strain, and non-Beijing strains were identified by spoligotyping. Of 200 specimens, 19 [9.5%] were Beijing strain and 181 [90.5%] were non-Beijing strains. The results of PCR for Beijing strains were as follows: 16 strains [84.2%] were positive for plcA, 17 [89.4%] were positive for plcB and 17 [89.4%] were positive for plcC genes. The standard strain [H37RV] was used as control. The majority of Beijing strains have phospholipase C genes which can contribute to their pathogenesis but we need complementary studies to confirm the role of phospholipase C in pathogenecity of Mycobacterium tuberculosis