Alterations in lipid profile in old age hypothyroid patients

The current investigation was designed to study the changes of lipid profile in hypothyroid patients in local population and t o investigate the importance of thyroid profile in oId age dyslipidemia patients. Ninety five newly diagnosed untreated h ypothyroid patients [aged 4 9.21 +/- 12.47 years, BMI 3 0.36 +/- 5.8, 74 females and 21 males] were identified from thyroid OPD of INMOL, PGMI, Lahore. Patients were compared with 78 control subjects [aged 48.80 +/- 11.00 years, BMI 30.51 +/- 04.70, 54 females and 24 males] matched by age and body mass index [BMI]. Serum TSH, FT4, FT3, Triacylglcerol [TAG], total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C] and high density lipoprotein cholesterol [HDL-C] were measured. Significantly increased levels of TC and LDL-C in overt hypothyroid patients were observed. No significant differences were found in HDL-C and TAG in overt hypothyroid patients as compared to the control group. Elevated levels of TC and LDL-C in hypothyroid patients represent an increased risk of ischaemic heart disease that requires therapeutic intervention. The deranged lipid profiles in hypothyroidism can not be corrected without the treatment for hypothyroidism in these patients. Therefore, all older patients referred for diagnosis and treatment of dyslipidemia should also be screened for hypothyroidism

Changes in electrolyte and blood urea in cirrhotic patients

Patients suffering from liver cirrhosis, age between 18 to 60 years both male and female were studied from Biochemistry Deptt, PGMI and Medical I, Services Hospital, Lahore. Out of total 49 patients were found to be positive for hepatitis B virus and 23 percent for hepatitis C virus. Serum bilirubin and alkaline phosphatase was highly significant [p<0.001, while alanine transferase moderately and total protein was non-significantly reduced. Blood urea was normal for majority of patients. Serum electrolytes were normal for potassium but decrease in sodium was non significant. Increase in serum bilirubin and alkaline phosphatase, slight decrease in serum sodium and normal potassium were frequent findings in liver cirrhosis