Curative effect of bone marrow cells transplantation and/or low dose gamma irradiation on liver injuries induced by carbon tetrachloride

Liver is the most common target for toxic injury. Toxic agents include chemicals such as carbon tetrachloride [CCl4] and trichloroethylene. This study aimed to evaluate the effect of bone marrow cells [BMC] transplantation and/or fractionated low doses [0.5 Gy] gamma radiation on established liver fibrosis induced by CCl4. BMCs of male albino rats were transplanted into 4-weeks carbon tetrachloride [CCl4]-treated and/or fractionated low doses [0.5 Gy] gamma irradiated rats through the tail vein, and the rats were treated for 4 more weeks with CCl4 [total 8 weeks]. Histological and ultrastructural investigations revealed that both bone marrow cells transplantation and low dose [0.5 Gy] gamma radiation exposure with continuous CCl4 injection had reduced liver fibrosis as compared with rats treated with CCl4 alone

[Corticosteroids and radiotherapy in the treatment of graves-ophthalmopathy]

Graves ophthalmopathy is a debilitating disease impairing the quality of life of affected individuals. The management of moderate-to-severe active Graves' ophthalmopathy is a major therapeutic challenge, and the treatment outcome is often unsatisfactory. We have carried out a retrospective study to assess the efficacy of combined orbital irradiation and systemic corticosteroids. Ten patients were included; all patients had received 20 Grays to the retrobulbar tissues in ten fractions, and oral or intravenous glucocorticoids. The main therapeutic outcome measures were the criteria of Donaldson and co-workers and a self-assessment evaluation. The quality of life outcome was also evaluated by the GO-QOL [Graves' ophthalmopathy quality of life] questionnaire. Seven patients [70%] demonstrated improvement in ocular parameters; the response was excellent in three cases, good in three cases and fair in one case. Three patients showed no response to the treatment. The self-assessment evaluation showed that 75% of patients were satisfied with the results of the treatment. Proptosis was the most responsive sign to radiation and steroids. A duration of the eye disease of more than 18 months was associated with less improvement and a higher failure of the treatment. Concerning the quality of life, the score for visual fonctionning was 88.2 +/- 18.2 after treatment, while the score for appearance was 63.3 +/- 23.3. In conclusion, a combination of orbital irradiation and systemic steroids is associated with 70% of favorable responses, but the quality of life is not restored in the same proportions and remains impaired after treatment