association between birth weight and adulthood body fat mass in women with poly cystic ovary syndrome

Polycystic ovary syndrome [PCOS] is the most prevalent endocrinopathy in reproductive aged women. The association of early-life factors such as fetal adipose tissue and birth weight with adulthood outcomes like obesity, body fat mass [BFM] and body lean mass [BLM] is not clearly understood. We aimed to compare the association between birth weight and body composition in women with PCOS and normal controls. For this study we enrolled a total of 70 reproductive aged women with PCOS diagnosis, referring to the Reproductive Endocrinology Research Center and the same number of healthy women without polycystic ovaries by ultrasonography or hirsutism and/or anyovulatory other dysfunction were enrolled. Their birth weights were documented and their body composition was assessed, using standard measuring devices. Cases were younger than the controls [29.7 +/- 4.9 versus 30.8 +/- 5.9 years] and had the same BMI [24.6 +/- 2.4 versus 24.8 +/- 4.5 kg/m2]. Our study demonstrated that BFM and BLM are increased in adult PCOS women born underweight, compared to their normal counterparts [16 +/- 4.7 versus 12.2 +/- 4.1, P= 0.06 and 46.4 +/- 5.8 versus 41.1 +/- 5.8, P=0.07]. The impact of fetal adipose tissue and birth weight on the occurrence adulthood obesity, BFM and BLM vary between women with and without PCOS

[Determination and comparison of estimated menopausal age based on serum anti-mullerian hormone in women with and without polycystic ovarian syndrome]

Menopause is defined as 12 months of constant amenorrhea in the absence of any pathology. Right now there is no definite test to predict menopause age and the ovarian reserve evaluations are mainly implemented on the basis of sonographic and hormonal measurements. The present study was conducted to determine and compare the menopausal age in women with polycystic ovarian syndrome [PCOS] and non PCOS women based on anti-mullerian hormone [AMH]. The present study is an epidemiologic case- control research in which from among 1019 women aged 20-40 years, 208 PCOS women and 811 normo-ovulatory controls were selected as the case and control groups respectively. Data collection was done through completing questionnaire, clinical examination and lab test measurements. After age and body mass index [BMI] matching, AMH levels in relation to age were displayed in an interactive graph and SPSS software version 21 was used for statistical analysis. Findings showed the mean age and BMI for case and control groups were 29.75 years - 27.1 [kg/m[2]] and 31.62 years - 26.1 [Kg/m[2]] respectively. Our results indicated significantly higher AMH levels in PCOS cases than in normal controls [P<0.0001]. The estimated menopausal age for PCOS and non PCOS women was 51 and 49 years respectively. To conclude PCOS patients reach menopause two years later than healthy women. If the length of reproductive period in these patients is higher than that the healthy women, it may be possible to use this period for increasing the fertility likelihood

[ simpler diagnostic method to assess Hirsutism in the Iranian population: based on modified Ferriman-Gallwey scoring system [Tehran lipid and glucose study]]

Hirsutism is a common endocrine disorder among reproductive women. There is no clear definition and criterion for the clinical evaluation and diagnosis of hirsutism. The aim of present study is to introduce a simpler diagnostic method on the basis of modified Ferriman-Gallwey [mF-G] system, which examines fewer body areas, but with the same sensitivity, specificity and positive predictive value [PPV]. A one thousand women, aged 18-45 years, participants of the Tehran Lipid and Glucose Study, were recruited by random systematic sampling. Data were collected by a questionnaire and clinical examination. The total mF-G score was calculated and ROC curve was drawn for subsets of areas. The new cut-off points were calculated for those subsets with optimal sensitivity, specificity, positive and negative predictive value and concordance percentage. The subset of 5 areas of the lips, chin, thighs, upper and lower abdomen [cut-off point 5], had sensitivity and specificity of 97/5% and 89/9% [R[2]= 0/92%, P<0.0001] respectively, and was the nearest subset to mF-G method. The subset of lip, abdomen and thighs [cut-off point 4] was 91/5% sensitive and 92% specific, with the highest PPV [72/2%] and concordance percentage [91/9%] with the golden standard [mF-G score >/= 8]. Using the 3 area subset of lip + lower abdomen + thighs serves as a simple and more accepted method for hirsutism assessment and can be used in wide epidemiologic studies