RESUMO
The aim of this prospective study in Morocco was to investigate the causes of invasive bacterial diseases in children in order to inform antibiotic therapy and vaccine choices. Of 238 children aged = 5 years admitted to the Children's Hospital of Casablanca for invasive diseases over a 12-month period, 185 were diagnosed with bacterial infection: 76 had chest-X-ray-confirmed pneumonia, 59 had meningitis and 50 had sepsis. Streptococcus pneumonia was the most common pathogen identified [n= 24], followed by Neisseria meningitides [n= 18, all group B] and Haemophilus influenza [n= 11]. The rate of penicillin non-susceptibility was 62.5% among Str. pneumoniae isolates and 11.1% among N. meningitidisand all isolates were ceftriaxone-susceptible. Of the 11 H. influenzae isolates, only 1 produced a beta-lactamase. The 5 predominant Str. pneumoniaeserotypes were 19F, 14, 23F, 6B and 19A and the theoretical coverage of the 7, 10 and 13-valent pneumococcal conjugate vaccines was 60%, 78% and 91% respectively
Assuntos
Criança , Testes de Sensibilidade Microbiana , Sorotipagem , Estudos Prospectivos , Pneumonia , Meningite , Sepse , Streptococcus pneumoniae , Neisseria meningitidis , Haemophilus influenzae , Penicilinas , CeftriaxonaRESUMO
Rofecoxib [selective cycIo-oxygenase-2-inhibitor] had a wide range of surgical therapies especially [analgesic] in the peri-operative period. Its effects on the intestinal wound healing is unknown. The aim of the studied was to investigate effects of Rofecoxib on colonic anastomosis in rats in the first post-operative week. The study included 40 male rats divided into two groups, studied, 20 and control 20. In both, resection-anastomosis of left colon with interrupted single layer of vicryl 6/0 was done. The control group received distilled water and the studied group received Rofecoxib pre-operatively and during the first post-operative week. Bursting pressure of the anastomosis in the studied group decreased from 116.40 + 10.20mmHg preoperatively to 41.60 + 3.00 mmHg and 49.40 + 5.79 mmHg respectively at 3 and 7 days post-operatively [P<0.001] compared to 124.05 + 11.15 mmHg, 107.70 + 12.90 mmHg and 114.55 + 12.91 mmHg respectively in the control group at the same intervals. Epithelialization 0f grade I with numerous inflammatory cells was noted in the anastomosis in the studied group at the third post-operative day, while epithelialization of grade III and less numerous inflammatory cells together with reformed lamina propria and congested blood vessels were noted at the seventh post-operative day. Incidence of colonic of fistula was 33% in the studied group versus 9% in the control group at the seventh post-operative day While mortality was 25% in the studied group compared to 9% in the control group at the seventh post-operative day. No fistula or mortality occurred on the third post-operative day. In conclusion, administration of Rofecoxib significantly impaired healing [decreased cellular proliferation and collage deposition] and decreased bursting pressure of colonic anastomosis in rats during the first post-operative week. Rofecoxib increased incidence of fistula in this period