RESUMO
Background: Coronary artery disease is mainly caused by atherosclerosis and its complications. Platelets and their activity have an important role in initiation of atherosclerotic lesions and coronary thrombus formation. Larger platelets are enzymatically and metabolically more active and have a higher potential thrombotic ability as compared with smaller platelets. Aim: To compare platelet volume indices in acute myocardial infarction, unstable angina, stable angina pectoris and healthy controls and to investigate the importance and role of platelet volume indices in acute coronary syndrome. Materials and methods: This was cross-sectional study of 100 patients includes 25 patients with acute myocardial infarction, 25 patients with unstable angina, 25 patients with stable angina and 25 healthy controls. Venous samples would be drawn at the time of admission before initiation of treatment. Platelet volume indices were assayed within 30 minutes of blood collection, using auto analyser. Results: Platelet volume indices were found to be higher among ACS (acute myocardial infarction and unstable angina) patients as compared to non ACS (stable angina and healthy control). For example mean platelet volume was significantly higher in patients with AMI (9.8±0.86) and unstable angina (9.5±0.84) as compared to stable angina (8.4±0.58) and healthy control (8.2±0.56). Conclusion: Measurement of platelet volume indices may be of benefit in detecting those patients at higher risk for acute coronary syndrome in future.
RESUMO
The human ovary is characterized by early senescence and the end stage of ovarian activity is termed menopause. The age at which menopause occur is between 45 and 55 years world wide. The objective of this pilot study is to determine the age at menopause by using a model of FSH over age in women of sub urban region around Chennai, India. The subjects include 500 patients of age between 30 and 36 yrs with BMI ranging from 24-28. After recording their general profile and history, blood samples were obtained by venipuncture and hormone FSH was estimated on the day 3 of the menstrual cycle. Based on functional dependence of FSH in the form of exponential relation with age, a model was proposed. Using least square approximation the beta values were calculated. With the help of beta values and using the cut off value of 40 IU/ml for FSH, this predicted model determined the age of menopause as 44.6 yrs in women of sub urban region around Chennai. The age of menopause is different in various region worlds wide. According to this pilot study the suburban women of Chennai, attain menopause at an age of 44.6 years. Further exploration should be done to alleviate the role of diet, life style and ethnic variation on menopausal age and the impact of chronic disease like osteoporosis during the period of menopause