Metastatic carcinoma of cervix mimicking psoas abscess on imaging: a case report / 부인종양

Cervical cancer can be presented as an unusual and aggressive manner in human immunodeficiency virus (HIV)-positive women. There are case reports of psoas abscess which mimick metastasis from cervical carcinoma in HIV-positive patients. However, such cases are very rare in HIV-negative women with only few case reports available in the literature. We report one case of psoas abscess mimicking metastasis in a HIV-negative woman, which was initially diagnosed as spinal tuberculosis.

Ototoxicity by aminoglycosides a clinical study in an Apex Hospital

To study the drugs causing ototoxicity, their likely mechanism and developing rational approach for prevention and management of this therapeutic problem. Patients attending OPO and IPD with any evidence of drug-induced ototoxicity were included in the study and they were further evaluated by detailed history of drug exposure to find out drug responsible for ototoxicity and then local and audiometric examination of ear was done to find out the type and extent of hearing impairment the relevant drugs produced. 100 patients of ototoxicity caused by various aminoglycosides were studied and observed that Streptomycin is the commonest aminoglycoside and tinnitus is the commonest manifestation of aminoglycoside-induced ototoxicity. Aminogtycoside causes initial high frequency hearing loss which in severe cases also involves normal speech frequencies, a significant hearing loss had already been established in most of the patients before the hearing impairment became apparent to patients or even to prescribing physician, so these drugs should be avoided where possible or preventive measures must be applied at least in high risk individuals

3-Dimensional conformal radiotherapy versus intensity modulated radiotherapy for localized prostate cancer: dosimetric and radiobiologic analysis

To analyze the dosimetric and radio biologic advantages between intensity modulated radiotherapy [IMRT] and 3 dimensional conformal radiotherapy [3DCRT] and selection of optimal photon energy for IMRT treatments. 24 patients with localized prostate carcinoma were planned for 3DCRT and IMRT techniques. Radiation dose of 54 Gy with 2 Gy/fraction, was planned to Planning target volume [PTV1] [prostate + seminal vesicle + 1 cm margin] and 72 Gy to PTV2 [prostate + 1 cm margin] respectively. 3DCRT planning was done using 15 MV photon beam while IMRT plans were created using 6 MV and 15MV photons. Treatment plans were analyzed using mean, median, dose maximum and cumulative dose volume histogram for PTV1, PTV2, bladder, and rectum. Tumor control probability [TCP] was calculated for prostate. Normal tissue complication probability [NTCP] was calculated for bladder, rectum, and head of femur. Mean dose to prostate was 72.79 +/- 0.18 Gy for IMRT 15 MV, 72.16 +/- 0.27 Gy for 3DCRT and 72.48 +/- 0.19 Gy for IMRT 6 MV. TCP was greater for IMRT 15 MV followed by IMRT 6 MV. The mean value of NTCP was significantly lower [p = 0.0015] for IMRT 6 MV compared to 3DCRT for rectum while for bladder all were comparable. IMRT techniques shows superiority in sparing surrounding critical organs, thus reducing normal tissue complication rates while maintaining the same or higher tumor control probability. No significant difference was observed between IMRT 6 MV and IMRT 15 MV techniques.

Drug induced hearing impairmenta - pilotstudy

The aim of the study is to observe the drugs causing hearing impairment, their likely mechanism and developing rational approach for prevention and management of this therapeutic problem. Patients attending OPD and IPD with any evidence of drug induced ototoxicity were included in the study and they were further evaluated by detailed history of drug exposure and local and audiometric examination of ear to find out the type and extent of hearing impairment and drugs responsible for ototoxicity. 120 patients of ototoxicity caused by various drugs and of varying degrees were included in the study and we observed that aminoglycosides are the most common cause and tinnitus is the most common manifestation of ototoxicity. Hearing impairment is initially of high frequency which in severe cases also included abnormal speech frequencies.A significant hearing loss had already established in most of the patients before the hearing impairment became apparent to patients or even prescribing physician, so these drugs should be avoided where possible or preventive measures must be applied at least in high risk individuals