RESUMO
<p><b>INTRODUCTION</b>A few electrocardiographic criteria have been described to identify the infarct-related artery in inferior myocardial infarction. The aim of this study was to devise an arithmetic score to further improve the diagnostic accuracy.</p><p><b>MATERIALS AND METHODS</b>From 2004 to 2006, 78 patients who underwent primary angioplasty for inferior myocardial infarction within 6 hours from symptom onset were recruited for electrocardiographic and angiographic analysis.</p><p><b>RESULTS</b>The mean age of patients was 65 ± 12 years with male predominance (74%). Less ST depression in lead I and aVL, and more prominent ST depression in lead V1-3 were observed in left circumflex artery (LCX) than right coronary artery (RCA) occlusions. In addition, more prominent ST depression in lead I and ST elevation in V1 were found in proximal RCA than distal RCA occlusions. Based on the findings, the Jeopardised Inferior Myocardium (JIM) score was constructed and defi ned as [II-V3/III+V1- I]. The sensitivity and specificity of JIM score ≤0.5 to predict proximal RCA occlusions; 0.5 <JIM score ≤1.5 to predict distal RCA occlusions; and JIM score >1.5 to predict LCX occlusions were 58% and 85%, 69% and 68%, and 79% and 94%, respectively. The accuracy of prediction is slightly better than the 2 previously reported criteria.</p><p><b>CONCLUSION</b>By taking into account more leads, the JIM score is capable of identifying the infarct-related artery with an improved diagnostic accuracy.</p>
Assuntos
Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Algoritmos , Angiografia Coronária , Oclusão Coronária , Diagnóstico , Vasos Coronários , Patologia , Eletrocardiografia , Métodos , Infarto Miocárdico de Parede Inferior , Diagnóstico , Valor Preditivo dos Testes , Sensibilidade e EspecificidadeRESUMO
The aim of the present study was to [1]. Investigate and analyze the role of genetic factor in breast cancer from Malaysian patients with either early-onset breast cancer [at age = 45 years] or a positive family history. [2]. Possible set up of a screening and diagnostic kit. 3. Possible development of drug formulation against breast cancer. In collaborating with the IIUM Breast Centre and the Surgery Department at Hospital Tingku Ampuan Afzan [HTAA], Kuantan, 100 peripheral blood samples were collected from women with either early-onset breast cancer of a positive family history of breast cancer. Mutations were detected in exon 11 of BRCA1 gene by Protein Truncation Test [PTT] further sequencing was carried out. We could not observed any truncated protein in any of the 100 samples. In spite of reports in literature from other countries documenting evidence of protein truncation mutations in exon 11 BRCA1 gene in early onset breast cancer patients, no such mutations were detected in this study. This probably implies that for patients from this region, one should look for mutation in other segments of exon 11