Effect of non steroidal anti-inflammatory drugs on the diuretic effect of bumetanide in rats

This study was designed to explore the possibility of interaction between non-steroidal anti-inflammatory drugs [NSAIDs] and loop diuretics [bumetanide] using selective cyclooxygenase-2 [COX-2] inhibitor [meloxicam] and non- selective cyclooxygenase inhibitor [indomethacin]. Animals were divided into six groups, each contained 16 rats. Four rats of each group were caged in a metabolic cage designed for urine collection. The results of this study were presented and discussed

Effect of angiotensin converting enzyme inhibitors on gentamicin nephrotoxicity in rats

The effect of two angiotensin converting enzyme inhibitors; namely, captopril [1.8 mg/kg/day orally] and enalapril [0.8 mg/kg/day orally] on gentamicin induced nephrotoxicity [each given seven days pretreatment for 14 days concomitantly with gentamicin] was studied in rats. Treatment with gentamicin [40 mg/kg/day IP for 14 days] resulted in an increased serum malondialdehyde and a significant decrease of urinary prostaglandin E2. It could be concluded that angiotensin converting enzyme inhibitors were of a significant value in the protection against nephrotoxic insults and they are worth to be tried clinically

Effect of silymarin on some nephrotoxic drugs in rats

The aim of this study was to examine whether silymarin could protect against renal injury due to the nephrotoxic drugs as gentamicin and cisplatin. Animals were subdivided into six groups, each containing ten rats: The first group was used as a control and received normal saline orally at a dose of 0.5 ml/day for seven days, the second group was treated with silymarin orally at a dose of 200 mg/kg/day for seven days, the third group was treated with gentamicin at a dose of 80 mg/kg/day IP for seven days, the fourth group was treated with cisplatin at a single dose of 5 mg/kg IV infusion and the fifth and sixth groups were pretreated with silymarin for seven days. The present data showed clearly the protective effect of silymarin against experimentally induced nephrotoxicity

Evaluation of the possibility of prophylactic and therapeutic effects of praziquantel in adjuvant arthritic rats

This work was designed to study the effect of praziquantel [an antibilharzial drug] on adjuvant arthritis in rats in comparison with indomethacin. An animal model of adjuvant arthritis was adopted in rats by intradermal injection of Freund's adjuvant. Oral administration of praziquantel in adjuvant arthritic rats at a dose of 187 mg/kg/week for four weeks as a prophylactic or therapeutic regimen resulted in a significant anti-inflammatory effect which was more or less similar to indomethacin. It was concluded that the administration of praziquantel could be used for the treatment of rheumatic diseases and it could prevent the progress of the rheumatic disease

Effect of exogenous calcium ions on prostaglandin output from rat hepatic tissue slices

This vitro study was an attempt to study the possible role of Ca[++] ions on metabolism of prostaglandins in hepatic tissue of albino rats. Addition of calcium ions in the form of calcium gluconate 10% ampule in a dose of 29 ug/gm wet tissues to the Kreb's Ringer phosphate media cause a high significant increasre in PGE[2] output from hepatic tissue slices. This is associated with a significant decrease in PGF[2]. These fingings may give an additional information of the possible role of Ca[++] ions on catabolism of prostaglandins. From the present study, it is concluded that addition of extracellular Ca[++] ions to the incubation media resulted in increase PGE2 synthesis and efflux with decrease PGE2 synthesis and efflux from hepatioc tissue of albino rats. The effect of Ca[++] ions on prostaglandins synthesis and release must be put in mind on using drugs which alter PG synthesis, efflux or both. An example of these drugs are calcium channel blockers, beta adrenergic receptor stimulator as well as alpha adrenergic receptor stimulator, which are commonly used in the treatment of many cardiovascular diseases. Their use must be put under observation to avoid undesirable effects as a result of increase or decrease prostaglandins formation