Epidemiology of human brucellosis in Ferdows, Sarayan and Boshrooyeh counties of southern Khorasan province in 2004-2005

Brucellosis is a bacterial zoonosis transmitted directly or indirectly to humans from infected animal. In this research human cases of brucellosis in three counties of southern Khorasan province since April 2004 until March 2005 were studied. In this prospective descriptive study, human cases with symptoms that suspicions to brucellosis pulse Wright titer

Comparison of efficacy of topical tretinoin 0.05% cream with placebo in treatment of melasma

Melasma is a common disorder of macular hyperpigmentation, which involves mostly in sun-exposed areas of face and neck. Women are more affected. Multiple factors have been postulated to involve in the etiology and pathogenesis of melasma including pregnancy, oral contraceptives, genetics, sun exposure, cosmetics and race. Fifty women completed a randomized, double blind vehicle controlled clinical trial, in which they applied 0.05% tretinoin [n=25] or vehicle cream [n=25] once daily on the face for 12 weeks. 2 weeks after treatment 6 out of 25[24%] tretinoin-treated patients [group 1] were clinically improved, compared with 0 out of 25[0%] in the vehicle group [group2][p=0.022]. 4 weeks after treatment 14[56%] of groupl and 5[20%] of group2 improved [p=0.006]. After 12 weeks, 21 [84%] of groupl and 6[24%] ofgroup2 were improved [p=0.0001] which demonstrated significant improvement in the tretinoin-treated patients compared with the vehicle group. This controlled study demonstrates that topical 0.05% tretinoin alone is considered to be effective in the treatment of melasma patients