RESUMO
Fourteen subjects with non-insulin dependent diabetes mellitus [NIDDM] [8 males and 6 females] with normal plasma high density lipoprotein-cholcstcrol [HDL-C] [54 +/- 14.9 mg/dl] group I were compared to 20 patients with NIDDM [8 males and 12 females] with low plasma HDL-C [29 +/- 4.8 mg/dl] group 2. These subjects were selected from subjects attending the diabetes clinic at the Main Alexandria University Hospital according to plasma HDL-C levels. Mean age, duration of diabetes, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, fasting plasma total cholesterol, low density lipoprotein-cholesterol, and C-peptide levels were comparable in both groups. Mean fasting plasma triglycerides [TG] was significantly elevated in group 2 [267.9 +/- 147.1 mg/dl] compared to that in group 1 subjects [150 +/- 29.7mg/dl] [P]. A significant inverse correlation was observed between plasma TG and HDL-C [P]. We can conclude that the decrease in HDL-C observed in some patients with NIDDM is not related to the degree of glycemic control, duration of diabetes, or insulin secretion; and that the reduction in HDL-C is associated with increase in TG