Pyrvinium pamoate with piperazine in the treatment of enterobiasis and ascariasis

The efficacy and tolerance of CI-578 suspension (combination of pyrvinium pamoate and piperazine) against ascariasis and enterobiasis was determined. Patients were 103 children with enterobiasis including 98 with concurrent ascariasis. CI-0578 suspension was given as a single dose on 2 consecutive days. The daily dose provided 2.5 mg. of pyrvinium per kg. and 75 mg. of piperazine per kg. Two weeks after treatment, 84% of all patients were negative for Enterobius eggs. Overall reduction of Ascaris eggs was 95% with 74% of the 98 patients negative after treatment. CI-578 was well tolerated and well accepted. Mild and transient nausea occured in 9 children. (Summary)

A report of two schistosomiasis endemic municipalities in northwestern Leyte

The results of the schistosomiasis survey in Matag-ob and Villaba of Northwestern Leyte showed 78 school children out of the 385 examined to be positive for S. japonicum ova in their stools. Snail surveys revealed the presence of O. quadrasi which were naturally infected with S. japonicum cercariae. The endemicity of schistosomiasis japonica in these places is therefore established. Treatment of cases, intensive environmental sanitation and health education work are being carried out by the Provincial Health Office and Rural Health Units of these two Municipalities. (Author)

Niridazole in the treatment of schistosomiasis japonica

This paper presents drug trials with Niridazole, an oral schistosomicide. Seventy-two of 106 patients who complemented treatment and who were followed-up monthly for 6 months gave a cure rate ranging from 48.3% to 84.8% and a highly satisfactory egg reduction in the stool of 96.3% to 98%. However, due to transient psychic side reactions observed in some patients, it is recommended that treatment with this drug be done under close medical supervision.(Auth. Abs.)

A preliminary report of early schistosomiasis japonica cases treated with sodium antimony dimethylcysteine tartrate (NaP)

A total of 10 adult patients suffering from early schistosomiasis japonica at the Bethany Hospital, Tacloban City with daily injections of Sodium Antimony Dimethylcysteine Tartrate (NaP) for 5 days at 400 mgs./day. Two had severe reactions consisting of nausea, vomiting and body weakness. Cardiac toxicity was observed in nine cases which developed reversible myocardial ischemic injury. A 100% cure rate from one to six months of stool follow-up after treatment was obtained. The exact value of this drug for mass treatment however, will depend on further evaluation of its toxicity and efficacy with a different dosage and/or schedule between injections.(Auth. Abs.)

Further trials with stibophen in the treatment of schistosomiasis japonica

In view of the absence thus far of a more effective and less toxic schistosomicide, a review and more thorough evaluation of the efficacy of stibophen was carried out. Three different schedules of treatment were tried wherein 10 and 15 injections were given every other day (Schedule I and II respectively) and 15 injections with 2 days interval between injections (Schedule III). A dose of 1 cc/10 kg. body weight per injection was used. Follow-up of the treated patients for a period of 6 months showed that Schedules II and III with mean cure rates of 66.4% and 53.4%, respectively, were better than Schedule I. Mild to moderate reactions occurred in majority of the patients treated with two having severe body weakness so that treatment had to be continued. Generally, less reactions were observed among children compared to adults. For the treatment of cases therefore, the use of 15 injections given either every other day or every fourth day is recommended especially among children 14 years and below.(Auth. Abs.)