RESUMO
The acetycholine-cholinesterase sytem has often been implicated in the regulation of transport across biological membranes. Drugs affecting such systems are, therefore, of much interest to most investigators in this field and one of these is Hemicholinium No. 3, otherwise known as "HC3"HC-3 has been known to produce marked respiratory paralysis, possibly due to inhibition of acetylcholine systnesis through a block in choline transport across nerve membranes. The role of choline in lipid metabolism and in nervous transmission has been well established. Any alterations in the choline transport may, therefore, manifest in some derangement in the biochemical reactions involving such mechanisms, eventually leading to a disturbance in function. Moreover, any drug inhibiting such transport mechanism, may be expected to manifest signs to choline deficiency