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Chinese Journal of Natural Medicines (English Ed.) ; (6): 546-549, 2017.
Artigo em Inglês | WPRIM | ID: wpr-812082

RESUMO

Tagetones A (1) and B (2), two new monocyclic diterpenoids were isolated from the n-hexane fraction of fresh flowers of Tagetes minuta L. (Asteraceae). Their structures were established by multiple spectroscopic methods (IR, HR-ESI-MS, and 1D-, and 2D-NMR), in addition to comparison with literature data. Compound 1 showed cytotoxic activity towards MCF7 and A549 cancer cells with IC values being 4.68 and 4.24 µmol·L, respectively, compared to doxorubicin (IC 0.13 and 1.12 µmol·L, respectively). Compound 2 also exhibited significant activity against HCT116 cancer cells (IC, 6.30 µmol·L).


Assuntos
Humanos , Linhagem Celular Tumoral , Sobrevivência Celular , Diterpenos , Química , Farmacologia , Flores , Química , Extratos Vegetais , Química , Farmacologia , Tagetes , Química
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