RESUMO
To provide pharmacological evidence of plumeria rubra as antipyretic agent in practice many parts of Pakistan. Antipyretic effect of methanolic extract of the bark of plumeria rubra was investigated.on yeast , dinitrophenol and E-coli induced model. Intraperitoneal administration of yeast, dinitrophenol and E-coli in albino rabbits leads to pyrexia. Intraperitoneal administration of methanolic extract of the bark of plumeria rubra at a dose 100mg/kg body weight were shown significantly reduce the elevated body temperature of rabbit in yeast induced model which was compared with aspirin (Standard Drug) and solvent used. In dinitrophenol induced pyrexia, mixture of verapamil (2mg/kg) and Plumeria rubra (50mg/kg), while in In E-coli induced pyrexia, mixture of Ciproflaxacin (10mg/kg) and Plumeria rubra (50mg/kg), significantly reduced the elevated temperature in all models as compared to the standard drug Aspirin.