RESUMO
Aim: The aim of this study was to design multi-walled carbon nanotubes [MWCNTs] loaded with paclitaxel [PTX] anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer
Background: Carbon nanotubes [CNTs] represent a novel nano-materials applied in various fields such as drug delivery due to their unique chemical properties and high drug loading
Patients and Methods: In this study, multi-walled carbon nanotubes [MWCNTs] pre-functionalized covalently with a paclitaxel [PTX] as an anti-cancer drug and evaluated by different analyses including, scanning electron microscope [SEM], particle size analyzer and cellular analyses
Results: A well conjugated of anti-cancer drug on the carbon nanotube surfaces was shown. This study demonstrates that the MWCN-PTX complex is a potentially useful system for delivery of anti-cancer drugs. The flow cytometry, CFU and MTT assay results have disclosed that MWCNT/PTXs might promote apoptosis in MKN-45 gastric adenocarcinoma cell line
Conclusion: According to results, our simple method can be designed a candidate material for chemotherapy. It has presented a few bio-related applications including, their successful use as a nano-carriers for drug transport
RESUMO
Schizophrenia is a mental disorder painful with prevalence of about 1% in the world. Nowadays, there is no experimental test aiding the accurate diagnosis of schizophrenic patients but recently quantitative determination of some serum proteins led to many investigations on the roles of these in neuropsychiatric.In the present study, our aim is to quantitative determination ApoA1 and IgM between 134 schizophrenic patients and 127 healthy control persons. Schizophrenia patients were selected from the Tehran Razi hospital. The age [p=0.53] and sex distributions of schizophrenic patients were similar to those of control persons. We measured ApoA1 and IgM levels by immunoturbidimetry method. P<0.05 was considered significant. ApoA1 showed a significant decrease in serum [p=0.00] and IgM to be significantly increased [p=0.00].Furthermore, female patients showed an increase IgM more than males. These results for ApoA1 and IgM support other reports. Decrease ApoaA1 confirmed the relationship of lipid metabolism in schizophrenia patients, also increase IgM evaluate the impact of treatment. This report can help to identify disease markers and treatment such as immunoglobulin therapy or regulate lipid metabolism. It can be imagined that immunoglobulin therapy more effective in the female patients than male and need to expand about them