Serum Uric Acid Association with Diabetic Foot - Study at a Tertiary Care Center.

Introduction: Diabetic foot is considered as one of the dreaded complications of diabetes mellitus and the most common cause of lower limb amputations. There are various studies done which show that uric acid is an inflammatory factor could have a role play in the development of a role in endothelial dysfunction. In view of the above said facts that we considered this study to see if there is any association between serum uric acid level and diabetic foot. Materials and Methods: A prospective cross-sectional analytical was conducted on 42 diabetic foot patients who met the inclusion criteria. Venous blood samples were obtained in fasting state for determinations of serum creatinine, uric acid, and hemoglobin A1c 24-h urine protein. Statistical Analysis: Results were expressed as mean ± standard deviation, and all the results which will be having a P < 0.05 was considered as considered as statistically significant; the mean age of the patients was 58 ± 8.3 years. Mean ± standard error (SE) of serum creatinine was 068 ± 0.038 mg/dL and mean ± SE of serum uric acid was 4.9 ± 0.10 mg/dL. In this study, there was no significant difference of serum uric acid, glycosylated hemoglobin, and renal functions between males and females (P > 0.05). There was a significant positive association between body mass index and serum uric acid (P < 0.001). After adjustment for weight, a significant positive association of serum uric acid level with diabetic foot was seen (P < 0.001). Conclusion: Serum uric acid had a significant positive association with diabetic foot.

Fatty Changes in the Radiological Appearance of the Liver - Is there Any Significance.

Introduction: Sonography is the most commonly performed investigation in surgical practice, and fatty liver is the most common finding in routine screening of the abdomen. The liver is considered as the recycler of the human body. An organ par excellence, which has undertaken the task from the basic like nutrition provision in starvation to the utmost complicated one like detoxification. This organ is the brunt taker of the body being the recycler and detoxifier. Aim: In our study, we aimed at finding the incidence of fatty liver in symptomatic individuals and corelating with the lipid profile we also followed these patients who had normal lipid profile for a minimum period of 1-year to see if there were any changes in the lipid profile latter. Materials and Methods: This was a prospective cross-sectional study conducted at a medical college in South India. The study was conducted between January 2013 and December 2015. The study included 130 healthy individuals who were willing to part-take in the study after fulfilling a pre-defined criterion. The patients underwent ultrasonography of the abdomen to evaluate the liver; those found to have fatty liver were further evaluated for lipid and sugars. The data were analyzed. Results: Among the 130 participants, we found that 86 had fatty liver of which 25 had abnormal lipid profile, 16 were found to have acanthosis nigrans with impaired glucose, 8 were newly detected diabetes mellitus, and 3 were found to have hypothyroidism. Eight had both impaired glucose and lipid abnormalities. The 26 patients who had normal laboratory values were followed for a year and were found to have normal laboratory functions. Conclusion: Fatty liver found on routine scanning the abdomen for other causes need to be evaluated.