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Background: Amoebic liver abscess presents with severe pain and high grade fever and if not diagnosed and treated promptly, may lead to complications and mortality. Aim and objectives: The objective of the present study was to estimate the incidence, need for aspiration and prognosis. The diagnosis was based on clinical features, positive Elisa test, ultrasonography, aspiration of anchovy sauce from the liver lesion, isolation of E. Histolytica (cyst/trophozoite) from the stool of the patient. Result: We had 65 cases in the study. There were 52 males & 13 females with a ratio of 4:1. Solitary abscess was found in 48(73.8%) patients which are located as follows; right lobe(43), left lobe(2) and in both lobe(3). 9% were aspirated at presentation due to their size or position. Only 4 (2%) were aspirated at first follow-up on third day due to non resolution of pain or fever or increase in size. All the patients are responded to standard treatment of metronidazole. Amoebic liver abscess is a common diagnosis in our setup. Conclusion: Clinical background and sonogram give a reasonable suggestion about amoebic etiology. If initial aspiration is not indicated due to size larger than10 cm or proximity to surface, conservative treatment with oral or intravenous metronidazole is successful.
RESUMO
Pomegranate is a plant with high potential to have antimicrobial and antioxidant compounds. In the present study inedible parts (peel and seed) of pomegranate, variety “Bhagawa” were examined for the presence of phytochemicals, phenolic compounds, flavonoids, anthocyanin, antioxidant and anti-microbial compounds. Further, nutrition value of the samples was also examined. Results of GC-MS analysis carried out using four different solvents showed 12 and 25 fractions for peel and seed extracts respectively. Both peel and seed were with high amount of Anthocyanin, Phenolic compounds and Flavonoids. Both extracts gave 100% free radicals reduction in DPPH assay showing high antioxidant activity. Further, both extracts showed antibacterial activity against eight tested food borne pathogens. Antibacterial activity shown by peel extracts was higher than that of seed extract. Both peel and seed extracts showed highest and lowest antibacterial activity against Staphylococcus aureus and Listeria monocyatogenes respectively. Both extract showed same antibacterial activity which was shown by Kanamycin for Shigella fexneri. According to the present study, pomegranate peel and seed can be used to extract antibacterial, antioxidant compounds and flavonoids for the use in food industry.
RESUMO
Acute promyelocytic leukemia (APML), once highly fatal, has emerged as the most curable subtype of acute myeloid leukemia in adults. Early mortality most often is due to a severe catastrophic bleeding, often intracerebral in location. Here we report a 17year male patient presented with status epilepticus having high leukocyte count (3,28,000/mm3) and low platelet count(34,000/mm3).Peripheral blood & bone marrow was showing good no. of atypical promyelocytes. CT scan of brain revealed an intracerebral haemorrhage with laboratory profile of prolonged prothrombin time and activated partial thromboplastin time, the presence of Ddimer and decreased fibrinogen concentration. The patient was diagnosed as Acute Promyelocytic Leukemia with Intracerebral haemorrhage. The patient died on the same day. APML is the notorious subtype of acute myeloid leukemia which causes fatal intracranial haemorrhage which has high mortality and morbidity. Clinically significant coagulopathy is present in 70%– 80% of APML patients at the time of diagnosis. Early detection and aggressive correction of coagulopathy may prevent the catastrophic event. Prompt image study for locations and types of ICH can predict outcomes.