Assuntos
Adolescente , Animais , Criança , Pré-Escolar , Reações Falso-Negativas , Reações Falso-Positivas , Feminino , Humanos , Lactente , Recém-Nascido , Malária Falciparum/diagnóstico , Masculino , Plasmodium falciparum/isolamento & purificação , Kit de Reagentes para Diagnóstico/normas , Sensibilidade e EspecificidadeRESUMO
The present paper describes the advantage/limitation of presently available 'in-vivo' methods to detect sensitivity status of Plasmodium falciparum to commonly used antimalarial drugs. The paper is based on a retrospective analysis of 890 P. falciparum cases and various parameters used to define the level of drug resistance. The presented quantification methodology with weightage system to different epidemiological variables of resistance may provide a guideline as to the level of parasite resistance, and a switch over to another antimalarial of firstline treatment which is of the considerable importance to provide early diagnosis and prompt treatment to avert the severe cases/deaths due to malaria.
Assuntos
Animais , Antimaláricos/uso terapêutico , Resistência a Medicamentos , Planejamento em Saúde , Humanos , Índia/epidemiologia , Malária Falciparum/tratamento farmacológico , Plasmodium falciparum/efeitos dos fármacos , Prevalência , Estudos RetrospectivosRESUMO
Plasmodium falciparum sensitivity test in "in-vivo" carried out in 450 patients revealed, parasite clearance in 66.45 percent cases with 25 mgm/kg body wt of chloroquine. Mean parasite clearance time (MPCT) of sensitive and R I, resistant cases reached near parallelism with an early recrudescence in RI cases indicating stabilisation of genetic change in the parasite strain. The analysis of data revealed that proportionately higher resistance was recorded in coastal area having deciduous (wet) forest ecotype followed by plains of deciduous dry forest and semi arid/arid ecotypes.