Local cervical injection of PGE 2 for cervical ripening and induction of 1st trimester therapeutic abortion

Prostaglandins administration by different routes give promising results with respect to the process of ripening the cervix. The aim of this work was to evaluate the effect of local cervical injection of PGE[2] for cervical ripening and induction of first trimester therapeutic abortion. The study involved 20 pregnant patients and the drug used was PGE[2] which was administered by local cervical injection of 250 Ug. in each lip. After 6 hours observation period, surgical evacuation was performed, the degree of cervical softening and cervical diameter in mm. were assessed before and during the operation, and also the side effects were observed. The degree of change in cervical dilatation from 4.07 to 8.35 mm. was statistically significant, also the process of further dilatation was easy due to the significant increase in the cervical softening induced by the PGE[2]. No serious side effects were observed during the ripening period or during the instrumental evacuation. The main side effects were uterine colics [70%], nausea [15%] and diarrhea [5%]. The colics were mild and no analgesics were required

Identification of the microbial flora of the normal and diseased vagina in pregnant and non pregnant women

The vaginal flora was studied in 100 sexually active women [mean age 30 years, range 20-38]. 50 were pregnant and 50 non- pregnant. Each group included 30 women complaining of heavy vaginal discharge and 20 asymptomatic. High vaginal swabs were taken and subjected to full bacteriological study. Nearly all women either symptomatic or not harbor pathogenic or potentially pathogenic microorganisms. The predominant microorganisms were G. vaginalis, Lactobacilli, Diphtheroid, Micrococci and Staph. epidermidosis. It was concluded that the vaginal flora was similar regardless of vaginitis or amount of vaginal discharge and the major difference was more prevalence of known vaginal pathogens [T. vaginalis and C. albicans] among women with vaginitis. No attempt was made to seek viruses, chlamydia and mycoplasma

role of gardnerella vaginalis in non specific vaginitis

The presence of Gardenella vaginalis [GV] in the vagina of 50 women suffering from non specific vaginitis [NSV] was studied. The isolation rate of this organism was 86%. A wide variety of both aerobic and anaerobic organisms were recoered in association with G. Direct Gram stained smears reealed the presence of clue cells in 88% of cases. Amine test was positive in 70% of cases. Metronidazol [flagyl] 250 mg orally t.i.d. for seen days was given for 50% of studied cases, the other 50% of cases were given the preious treatment in combination with lactobacillus acidophilus, oestriol and progestrone [trophigil] intravaginally two times daily for seven days also. Two weeks later GV was recovered from 3 cases from the first group and from two cases from the second group